ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2015
Virome analysis of antiretroviral-treated HIV patients shows no correlation between T-cell activation and anelloviruses levels.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Cross-Compartment Virome Profiling in Human Immunodeficiency Virus Infection and Substance Use Disorder Reveals Brain-CSF-Periphery Discordance and Hepatitis B Virus in Central Nervous System.International journal of molecular sciences · 2026Article
- Anelloviruses: From General Biology to Their Role as Biomarkers of Immune Competence in HIV Infection.Viruses · 2026Review
- Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation.Aging and disease · 2025Review
- The Effect of Immunosuppressive Treatment on Torque Teno Virus Load in Lung Transplant Recipients: A Preliminary Study.Viruses · 2025Article
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- Plasma Virome of HIV-infected Subjects on Suppressive Antiretroviral Therapy Reveals Association of Differentially Abundant Viruses with Distinct T-cell Phenotypes and Inflammation.Current genomics · 2024Article
- Anelloviruses versus human immunity: how do we control these viruses?FEMS microbiology reviews · 2024Review
- Impact of HIV infection and integrase strand transfer inhibitors-based treatment on the gut virome.Scientific reports · 2022Article
- Association of post-transplantation anellovirus viral load with kidney transplant rejection in children.Pediatric nephrology (Berlin, Germany) · 2022Article
- Article
- Review
- The Human Virome: Viral Metagenomics, Relations with Human Diseases, and Therapeutic Applications.Viruses · 2022Review
- Detection and genetic characterization of the novel torque teno virus group 6 in Taiwanese general population.Royal Society open science · 2021Article
- Torque Teno Virus plasma level as novel biomarker of retained immunocompetence in HIV-infected patients.Infection · 2021Article
- Clinical Relevance of Torque Teno Virus (TTV) in HIV/HCV Coinfected and HCV Monoinfected Patients Treated with Direct-Acting Antiviral Therapy.Journal of clinical medicine · 2021Article
- Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.NPJ genomic medicine · 2021Article
- A Summary of the Fourth Annual Virology Education HIV Microbiome Workshop.AIDS research and human retroviruses · 2020Article
- Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India.PloS one · 2020Article
- Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis.Inflammatory bowel diseases · 2019Article
- TAR-VIR: a pipeline for TARgeted VIRal strain reconstruction from metagenomic data.BMC bioinformatics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAbnormally high levels of T-cell activation can persist in HIV-infected subjects despite effective anti-retroviral therapy (ART) and has been associated with negative health outcomes. The nature of the antigenic drivers or other causes of this residual T-cell activation remain uncertain. Anelloviruses are universally acquired soon after birth, resulting in persistent viremia, and considered part of the commensal human virome. Reduced immunocompetence results in increased anellovirus levels.
objectivesTo test whether increased levels of anelloviruses or other viruses in plasma are associated with higher levels of persistent T-cell activation during ART. STUDY
designTwo amplification methods combined with next generation sequencing were used to detect all viruses and estimate relative anellovirus levels in plasma from 19 adults on effective ART who exhibited a wide range of T-cell activation levels.
resultsNucleic acids from HBV and HCV were detected in one patient each while pegivirus A (GBV-C) was found in three patients. Anellovirus DNA was detected in all patients with some individuals carrying up to eight different genotypes. Specific anellovirus genotypes or higher level of co-infections were not detected in subjects with higher levels of T-cell activation. No association was detected between relative plasma anellovirus DNA levels and the percentage of activated CD4 or CD8 T cells.
conclusionsHuman anelloviruses were detected in all HIV suppressed subjects, exhibited a wide range of viremia levels, and were genetically highly diverse. The level of persistent T-cell activation was not correlated with the level of viremia or genotypes present indicating that anellovirus antigens are unlikely to be a dominant source of antigens driving chronic T-cell activation.
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