Evidence map›Paper›PMID 26479186›Full record

ArticleEndocrinology2016

Leptin Matures Aspects of Lung Structure and Function in the Ovine Fetus.

Miles J De Blasio, Maria Boije, Sarah L Kempster, Gordon C S Smith, D Stephen Charnock-Jones, Alice Denyer, Alexandra Hughes, F B Peter Wooding, Dominique Blache, Abigail L Fowden and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Does fetal leptin and adiponectin influence children's lung function and risk of wheeze?Journal of developmental origins of health and disease · 2021
    Article
  5. Article
  6. Obesity-associated asthma in childhood.Allergologie select · 2020
    Article
  7. Review
  8. Article
  9. The effect of obesity on lung function.Expert review of respiratory medicine · 2018
    Review
  10. Article
  11. Response to Torday.Pediatric research · 2017
    Article
  12. Article
  13. Drug target insights
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Miles J De BlasioDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Maria BoijeDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Sarah L KempsterDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Gordon C S SmithDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
D Stephen Charnock-JonesDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Alice DenyerDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Alexandra HughesDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
F B Peter WoodingDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Dominique BlacheDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Abigail L FowdenDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Alison J ForheadDepartment of Physiology, Development and Neuroscience (M.J.D.B., M.B., A.D., A.H., F.B.P.W., A.L.F., A.J.F.), University of Cambridge, Cambridge CB2 3EG, United Kingdom; Department of Medicine (S.L.K.), University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; Department of Obstetrics and Gynaecology (G.C.S.S., D.S.C.-J.), University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, United Kingdom; School of Animal Biology (D.B.), University of Western Australia, Crawley, Perth, Western Australia, Australia 60095; and Department of Biological and Medical Sciences (A.J.F.), Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
University of Cambridge · GBOxford Brookes University · GBRosie Hospital · GBUniversity of Western Australia · AU

Funding

Biotechnology and Biological Sciences Research Council BB/H01697X/1
6 · The paper itself

Abstract

In human and ovine fetuses, glucocorticoids stimulate leptin secretion, although the extent to which leptin mediates the maturational effects of glucocorticoids on pulmonary development is unclear. This study investigated the effects of leptin administration on indices of lung structure and function before birth. Chronically catheterized singleton sheep fetuses were infused iv for 5 days with either saline or recombinant ovine leptin (0.5 mg/kg · d leptin (LEP), 0.5 LEP or 1.0 mg/kg · d, 1.0 LEP) from 125 days of gestation (term ∼145 d). Over the infusion, leptin administration increased plasma leptin, but not cortisol, concentrations. On the fifth day of infusion, 0.5 LEP reduced alveolar wall thickness and increased the volume at closing pressure of the pressure-volume deflation curve, interalveolar septal elastin content, secondary septal crest density, and the mRNA abundance of the leptin receptor (Ob-R) and surfactant protein (SP) B. Neither treatment influenced static lung compliance, maximal lung volume at 40 cmH2O, lung compartment volumes, alveolar surface area, pulmonary glycogen, protein content of the long form signaling Ob-Rb or phosphorylated signal transducers and activators of transcription-3, or mRNA levels of SP-A, C, or D, elastin, vascular endothelial growth factor-A, the vascular endothelial growth factor receptor 2, angiotensin-converting enzyme, peroxisome proliferator-activated receptor γ, or parathyroid hormone-related peptide. Leptin administration in the ovine fetus during late gestation promotes aspects of lung maturation, including up-regulation of SP-B.

Indexed as

AnimalsDose-Response Relationship, DrugFemaleFetal TherapiesFetusGene Expression Regulation, DevelopmentalInfusions, IntravenousLeptinLungLung ComplianceOrganogenesisPregnancyPulmonary Surfactant-Associated Protein BRandom AllocationReceptors, LeptinRecombinant ProteinsLeptinPulmonary Surfactant-Associated Protein BReceptors, LeptinRecombinant ProteinsRNA, Messenger

Identifiers

PMID26479186
PMCPMC4701894
OpenAlexW1787163193

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.