ArticleNature2015
Structure of a eukaryotic SWEET transporter in a homotrimeric complex.
Article in Nature, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 221 citations in OpenAlex.
- The sugar transporter ZmSWEET11 participates in plant autophagy to respond to salt stress.GM crops & food · 2026Article
- Beyond prediction: Why experimental structural biology remains essential in plants.Current opinion in plant biology · 2026Review
- Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026Review
- Structural basis for pH-responsive amino acid transport via SLC7A4.Nature communications · 2026Article
- Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters.The Plant journal : for cell and molecular biology · 2026Review
- Towards a Holistic View of the Orchestration Between Sugar Transporters in Cereal Crops.Plants (Basel, Switzerland) · 2026Article
- Pan-genome analysis and abiotic stress expression of theFrontiers in plant science · 2026Article
- The secretion of Pseudomonas unconventional peroxidase facilitates extracellular carbon acquisition from heterogeneous lignin.Communications biology · 2025Article
- Functional Studies and Expression Characteristics of the Vacuolar Sugar Transporter CoSWEET2a inPlants (Basel, Switzerland) · 2025Article
- Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex.Nature communications · 2025Article
- Genome-wide identification of SWEET gene family and functional analysis of BcSWEET1-2 associated with flowering in flowering Chinese cabbage (Brassica campestris).BMC genomics · 2025Article
- The developmental basis of floral nectary diversity and evolution.The New phytologist · 2025Review
- How vacuolar sugar transporters evolve and control cellular sugar homeostasis, organ development and crop yield.Nature plants · 2025Review
- AlphaFold-Guided Bespoke Gene Editing Enhances Field-Grown Soybean Oil Contents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Genome-Wide Characterization, Comparative Analysis, and Expression Profiling ofInternational journal of molecular sciences · 2025Article
- Any1 is a phospholipid scramblase involved in endosome biogenesis.The Journal of cell biology · 2025Article
- Sugar transporters: mediators of carbon flow between plants and microbes.Frontiers in plant science · 2025Review
- The potato sugar transporter SWEET1g affects apoplasmic sugar ratio and phloem-mobile tuber- and flower-inducing signals.Plant physiology · 2024Article
- Disruption of the OsWRKY71 transcription factor gene results in early rice seed germination under normal and cold stress conditions.BMC plant biology · 2024Article
- Deep mutational scanning reveals sequence to function constraints for SWEET family transporters.bioRxiv : the preprint server for biology · 2024Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Eukaryotes rely on efficient distribution of energy and carbon skeletons between organs in the form of sugars. Glucose in animals and sucrose in plants serve as the dominant distribution forms. Cellular sugar uptake and release require vesicular and/or plasma membrane transport proteins. Humans and plants use proteins from three superfamilies for sugar translocation: the major facilitator superfamily (MFS), the sodium solute symporter family (SSF; only in the animal kingdom), and SWEETs. SWEETs carry mono- and disaccharides across vacuolar or plasma membranes. Plant SWEETs play key roles in sugar translocation between compartments, cells, and organs, notably in nectar secretion, phloem loading for long distance translocation, pollen nutrition, and seed filling. Plant SWEETs cause pathogen susceptibility possibly by sugar leakage from infected cells. The vacuolar Arabidopsis thaliana AtSWEET2 sequesters sugars in root vacuoles; loss-of-function mutants show increased susceptibility to Pythium infection. Here we show that its orthologue, the vacuolar glucose transporter OsSWEET2b from rice (Oryza sativa), consists of an asymmetrical pair of triple-helix bundles, connected by an inversion linker transmembrane helix (TM4) to create the translocation pathway. Structural and biochemical analyses show OsSWEET2b in an apparent inward (cytosolic) open state forming homomeric trimers. TM4 tightly interacts with the first triple-helix bundle within a protomer and mediates key contacts among protomers. Structure-guided mutagenesis of the close paralogue SWEET1 from Arabidopsis identified key residues in substrate translocation and protomer crosstalk. Insights into the structure-function relationship of SWEETs are valuable for understanding the transport mechanism of eukaryotic SWEETs and may be useful for engineering sugar flux.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.