Evidence map›Paper›PMID 26478902›Full record

ArticleJournal of alcoholism and drug dependence2015

Alcohol Versus Cannabinoids: A Review of Their Opposite Neuro-Immunomodulatory Effects and Future Therapeutic Potentials.

Madhavan P Nair, Gloria Figueroa, Gianna Casteleiro, Karla Muñoz, Marisela Agudelo

Open access · bronzeAbstract read
In one paragraph

Article in Journal of alcoholism and drug dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Alcohol and Cannabinoids - From the Editors.Alcohol research : current reviews · 2022
    Article
  8. Review
  9. Observational
  10. Cannabis and Alcohol: From Basic Science to Public Policy.Alcoholism, clinical and experimental research · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Severity and outcomes of acute alcoholic pancreatitis in cannabis users.Translational gastroenterology and hepatology · 2017
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Madhavan P NairDepartment of Immunology, Herbert Wertheim College of Medicine, AHC-I 417-B, Florida International University, Miami, FL 33199, USA.
Gloria FigueroaDepartment of Immunology, Herbert Wertheim College of Medicine, AHC-I 417-B, Florida International University, Miami, FL 33199, USA.
Gianna CasteleiroDepartment of Immunology, Herbert Wertheim College of Medicine, AHC-I 417-B, Florida International University, Miami, FL 33199, USA.
Karla MuñozDepartment of Immunology, Herbert Wertheim College of Medicine, AHC-I 417-B, Florida International University, Miami, FL 33199, USA.
Marisela AgudeloDepartment of Immunology, Herbert Wertheim College of Medicine, AHC-I 417-B, Florida International University, Miami, FL 33199, USA.
Florida International University · US

Funding

Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2R01DA034547 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2013 to 2018
$1.8M
EtOH-induced Immunomodulation: Role of Histone Deacetylases and Cannabinoid GenesR00AA021264 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI AGUDELO, MARISELA · 2015 to 2017
$735k
EtOH-induced Immunomodulation: Role of Histone Deacetylases and Cannabinoid GenesK99AA021264 · NIAAA · FLORIDA INTERNATIONAL UNIVERSITY · PI AGUDELO, MARISELA · 2013 to 2014
$176k
NIAAA NIH HHS K99 AA021264NIAAA NIH HHS R00 AA021264NIDA NIH HHS R01 DA034547
6 · The paper itself

Abstract

Due to the legalization of marijuana and the increased demand for cannabis and alcohol consumption, research efforts highlighting the biomedical consequences of the use of alcohol and cannabinoids are not only relevant to the substance abuse scientific field, but are also of public health interest. Moreover, an overview of the recent literature about alcohol and cannabinoids neuro-immunomodulatory effects highlighting their future therapeutic potentials will provide a significant contribution to science and medicine. Therefore, in the current review, we will first discuss briefly the prevalence of alcohol and marijuana abuse, followed by a discussion on the individual effects of alcohol and cannabinoids on the immune system; then, we will focus on the role of endocannabinoids on the alcohol-induced inflammatory effects. In addition, the review also incorporates cytokine array data obtained from human monocyte-derived dendritic cells, providing a different perspective on the alcohol and cannabinoid abuse divergent effects on cytokine production. The final section will highlight the therapeutic potential of cannabinoid receptors and the novel strategies to treat alcohol dependence as determined by in vitro, in vivo and clinical studies.

Indexed as

AlcoholCannabinoidsCytokinesImmune ModulationInflammation

Identifiers

PMID26478902
PMCPMC4607066
OpenAlexW2138999184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.