ArticleJournal of radiosurgery and SBRT
Factors that determine local control with gamma knife radiosurgery: The role of primary histology.
Article in Journal of radiosurgery and SBRT. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Factors associated with the local control of brain metastases: a systematic search and machine learning application.BMC medical informatics and decision making · 2024Pooled it
- Patterns of Failure Outcomes for Combination of Stereotactic Radiosurgery and Immunotherapy for Melanoma Brain Metastases.Neurosurgery practice · 2023Article
- Time interval from diagnosis to treatment of brain metastases with stereotactic radiosurgery is not associated with radionecrosis or local failure.Frontiers in oncology · 2023Article
- Hypofractionated frameless gamma knife radiosurgery for large metastatic brain tumors.Clinical & experimental metastasis · 2021Article
- Linac-Based Radiosurgery for Patients With Brain Oligometastases From a Breast Primary, in the Trastuzumab Era-Impact of Tumor Phenotype and Prescribed SRS Dose.Frontiers in oncology · 2019Article
- Surgical resection and postoperative radiosurgery versus staged radiosurgery for large brain metastases.Journal of neuro-oncology · 2018Article
- First follow-up radiographic response is one of the predictors of local tumor progression and radiation necrosis after stereotactic radiosurgery for brain metastases.Cancer medicine · 2017Article
- Stereotactic radiosurgery in the treatment of brain metastases from gynecologic primary cancer.Journal of radiosurgery and SBRT · 2017Article
- Optimal Treatment Decision for Brain Metastases of Unknown Primary Origin: The Role and Timing of Radiosurgery.Brain tumor research and treatment · 2016Article
- Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm.Journal of radiosurgery and SBRT · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundStereotactic radiosurgery for the treatment of brain metastases is commonly delivered without regard to primary cancer histology. This study sought to determine if the primary site of origin for brain metastases affected the propensity for local failure.
methodsA total of 83 patients with 200 brain metastases were examined retrospectively for predictors of infield failure. Tumor, patient, and treatment characteristics were analyzed including primary tumor histology, radiosurgical dose and age. Cox proportional hazards models, univariate and multivariate analyses were used to identify predictors of local failure.
resultsFreedom from local failure for the entire population was 83% and 65% at 6 and 12 months, respectively. Multivariate analysis revealed that breast cancer brain metastases have a significantly lower risk of local failure than melanoma (HR = 0.31, p< 0.001). Additionally, multivariate analysis revealed that increasing dose lowered risk for local failure (HR = 0.87, p<0.001).
conclusionsMelanoma histology leads to a higher rate of local failure. Higher prescription dose results in higher incidence of local control.
Indexed as
Identifiers
26478823PMC4605606W2470141702What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.