ArticleWater, air, and soil pollution
Over-the-Counter Monocyclic Non-Steroidal Anti-Inflammatory Drugs in Environment-Sources, Risks, Biodegradation.
Article in Water, air, and soil pollution. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 76 citations in OpenAlex.
- Photocatalytic degradation of ibuprofen on titanium oxide nanoparticles: insights into degradation kinetics, mechanisms, thermodynamics, pathways, and toxicity.RSC advances · 2026Article
- Article
- Biodegradation of paracetamol by Amycolatopsis sp. Poz 14.BMC research notes · 2025Article
- Laccases as Effective Tools in the Removal of Pharmaceutical Products from Aquatic Systems.Life (Basel, Switzerland) · 2024Review
- Hydroquinone Ecotoxicity: Unveiling Risks in Soil and River Ecosystems with Insights into Microbial Resilience.Toxics · 2024Article
- The contemporary nexus of medicines security and bioprospecting: a future perspective for prioritizing the patient.Natural products and bioprospecting · 2024Review
- Dendrimer Coated Silica as a Sorbent for Dispersive Solid-Phase Extraction of Select Non-Steroidal Anti-Inflammatory Drugs from Water.Molecules (Basel, Switzerland) · 2024Article
- Ibuprofen: Toxicology and Biodegradation of an Emerging Contaminant.Molecules (Basel, Switzerland) · 2023Review
- Electroanalysis of Ibuprofen and Its Interaction with Bovine Serum Albumin.Molecules (Basel, Switzerland) · 2022Article
- Xylitol as a Hydrophilization Moiety for a Biocatalytically Synthesized Ibuprofen Prodrug.International journal of molecular sciences · 2022Article
- Chronic levels of ibuprofen induces haematoxic and histopathology damage in the gills, liver, and kidney of the African sharptooth catfish (Clarias gariepinus).Environmental science and pollution research international · 2021Article
- Biodegradation and Kinetic Analysis of Acetaminophen with Co-culture of Bacterial Strains Isolated from Sewage Wastewater.Current microbiology · 2020Article
- Ibuprofen as an emerging organic contaminant in environment, distribution and remediation.Heliyon · 2020Review
- Organic micropollutants paracetamol and ibuprofen-toxicity, biodegradation, and genetic background of their utilization by bacteria.Environmental science and pollution research international · 2018Review
- Article
- Determination of acidic non-steroidal anti-inflammatory drugs in aquatic samples by liquid chromatography-triple quadrupole mass spectrometry combined with carbon nanotubes-based solid-phase extraction.Environmental monitoring and assessment · 2017Article
- Packed-bed bioreactor-based evaluation of Paracoccus sp. APAP_BH8 potential for acetaminophen biodegradation.Journal of environmental qualityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, the increased use of monocyclic non-steroidal anti-inflammatory drugs has resulted in their presence in the environment. This may have potential negative effects on living organisms. The biotransformation mechanisms of monocyclic non-steroidal anti-inflammatory drugs in the human body and in other mammals occur by hydroxylation and conjugation with glycine or glucuronic acid. Biotransformation/biodegradation of monocyclic non-steroidal anti-inflammatory drugs in the environment may be caused by fungal or bacterial microorganisms. Salicylic acid derivatives are degraded by catechol or gentisate as intermediates which are cleaved by dioxygenases. The key intermediate of the paracetamol degradation pathways is hydroquinone. Sometimes, after hydrolysis of this drug, 4-aminophenol is formed, which is a dead-end metabolite. Ibuprofen is metabolized by hydroxylation or activation with CoA, resulting in the formation of isobutylocatechol. The aim of this work is to attempt to summarize the knowledge about environmental risk connected with the presence of over-the-counter anti-inflammatory drugs, their sources and the biotransformation and/or biodegradation pathways of these drugs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.