Evidence map›Paper›PMID 26478601›Full record

ArticleJournal of computational physics2015

Hybrid approaches for multiple-species stochastic reaction-diffusion models.

Fabian Spill, Pilar Guerrero, Tomas Alarcon, Philip K Maini, Helen Byrne

Abstract read
In one paragraph

Article in Journal of computational physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  5. Article
  6. Spatially extended hybrid methods: a review.Journal of the Royal Society, Interface · 2018
    Review
  7. Article
  8. Article
  9. Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fabian SpillDepartment of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA ; Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Pilar GuerreroDepartment of Mathematics, University College London, Gower Street, London WC1E 6BT, UK.
Tomas AlarconCentre de Recerca Matematica, Campus de Bellaterra, Edifici C, 08193 Bellaterra (Barcelona), Spain ; Departament de Matemàtiques, Universitat Atonòma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Philip K MainiWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford OX2 6GG, UK.
Helen ByrneWolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford OX2 6GG, UK ; Computational Biology Group, Department of Computer Science, University of Oxford, Oxford OX1 3QD, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reaction-diffusion models are used to describe systems in fields as diverse as physics, chemistry, ecology and biology. The fundamental quantities in such models are individual entities such as atoms and molecules, bacteria, cells or animals, which move and/or react in a stochastic manner. If the number of entities is large, accounting for each individual is inefficient, and often partial differential equation (PDE) models are used in which the stochastic behaviour of individuals is replaced by a description of the averaged, or mean behaviour of the system. In some situations the number of individuals is large in certain regions and small in others. In such cases, a stochastic model may be inefficient in one region, and a PDE model inaccurate in another. To overcome this problem, we develop a scheme which couples a stochastic reaction-diffusion system in one part of the domain with its mean field analogue, i.e. a discretised PDE model, in the other part of the domain. The interface in between the two domains occupies exactly one lattice site and is chosen such that the mean field description is still accurate there. In this way errors due to the flux between the domains are small. Our scheme can account for multiple dynamic interfaces separating multiple stochastic and deterministic domains, and the coupling between the domains conserves the total number of particles. The method preserves stochastic features such as extinction not observable in the mean field description, and is significantly faster to simulate on a computer than the pure stochastic model.

Indexed as

Fisher–Kolmogorov equationHybrid modelLotka–Volterra equationReaction–diffusion systemStochastic model

Identifiers

PMID26478601
PMCPMC4554296

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.