ArticleJournal of veterinary internal medicine
Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Bile Culture, Antimicrobial Susceptibility, and Hepatobiliary Pathology in Dogs Undergoing Cholecystectomy for Gallbladder Mucocele.Animals : an open access journal from MDPI · 2025Article
- Evaluation of Hepatoprotectants in the Management of Subclinical Gallbladder Mucocele in Dogs.Animals : an open access journal from MDPI · 2025Article
- Nutritional Factors Related to Canine Gallbladder Diseases-A Scoping Review.Veterinary sciences · 2024Review
- Characteristics of gallbladder microbiome in healthy dogs and cats, dogs with gallbladder mucocele, and cats with suspected cholangitis/cholangiohepatitis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2024Article
- Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases.Animals : an open access journal from MDPI · 2023Article
- Multidrug resistant Enterococcus faecium isolate from cholangitis/cholecystitis in a dog.Veterinary medicine and science · 2022Article
- A multicenter retrospective study assessing progression of biliary sludge in dogs using ultrasonography.Journal of veterinary internal medicine · 2022Article
- Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver.Animals : an open access journal from MDPI · 2021Article
- Long-term survival of dogs treated for gallbladder mucocele by cholecystectomy, medical management, or both.Journal of veterinary internal medicine · 2019Article
- Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation.PloS one · 2019Article
- Gall bladder mucoceles in Border terriers.Journal of veterinary internal medicine · 2018Article
- Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation.PloS one · 2018Article
- Spontaneous Course of Biliary Sludge Over 12 Months in Dogs with Ultrasonographically Identified Biliary Sludge.Journal of veterinary internal medicine · 2016Observational
- Evaluation of gallbladder motility assessed by ultrasonography in dogs with hyperlipidemia.Journal of veterinary internal medicineArticle
- Comparison of fibroblast growth factor 19 concentrations between dogs with and without gallbladder mucoceles.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cause of gallbladder mucocele (GBM) formation in dogs currently is unknown. Many available drugs represent a newer generation of xenobiotics that may predispose dogs to GBM formation.
objectiveTo determine if there is an association between the histologic diagnosis of GBM in dogs and administration of selected drugs. ANIMALS: Eighty-one dogs with a histologic diagnosis of GBM and 162 breed, age, and admission date-matched control dogs from a single referral institution.
methodsMedical records of dogs with GBM and control dogs from 2001 to 2011 were reviewed. Owner verification of drug history was sought by a standard questionnaire. Reported use of heartworm, flea, and tick preventatives as well as nonsteroidal anti-inflammatory drugs, analgesics, corticosteroids, or medications for treatment of osteoarthritis was recorded.
resultsDogs with GBM were 2.2 times as likely to have had reported use of thyroxine (as a proxy for the diagnosis of hypothyroidism) as control dogs (95% confidence interval [CI], 0.949-5.051), 3.6 times as likely to have had reported treatment for Cushing's disease (95% CI, 1.228-10.612), and 2.3 times as likely to have had reported use of products containing imidacloprid (95% CI, 1.094-4.723). Analysis of a data subset containing only Shetland sheepdogs (23 GBM and 46 control) indicated that Shetland sheepdogs with GBM formation were 9.3 times as likely to have had reported use of imidacloprid as were control Shetland sheepdogs (95% CI, 1.103-78.239). CONCLUSIONS AND CLINICAL IMPORTANCE: This study provides evidence for an association between selected drug use and GBM formation in dogs. A larger epidemiologic study of Shetland sheepdogs with GBM formation and exposure to imidacloprid is warranted.
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