Evidence map›Paper›PMID 26478134›Full record

ArticleBrain research bulletin2016

Cue-reactivity in experienced electronic cigarette users: Novel stimulus videos and a pilot fMRI study.

Travis T Nichols, Jonathan Foulds, Jessica M Yingst, Susan Veldheer, Shari Hrabovsky, John Richie, Thomas Eissenberg, Stephen J Wilson

Abstract read
In one paragraph

Article in Brain research bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Vaping and Smoking Cue Reactivity in Young Adult Nonsmoking Electronic Cigarette Users: A Functional Neuroimaging Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  4. Article
  5. Article
  6. Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024
    Article
  7. Cue Reactivity to Electronic Cigarettes: A Systematic Review.Substance abuse : research and treatment · 2022
    Review
  8. Article
  9. Cigarette and e-cigarette use and social perceptions over the transition to college: The role of ADHD symptoms.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Travis T NicholsDepartment of Psychology, The Pennsylvania State University, University Park, PA, United States. Electronic address: travis.nichols.psu@gmail.com.
Jonathan FouldsDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, United States.
Jessica M YingstDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, United States.
Susan VeldheerDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, United States.
Shari HrabovskyDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, United States.
John RichieDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, United States.
Thomas EissenbergCenter for The Study of Tobacco Products, Department of Psychology, Virginia Commonwealth University, Richmond, VA, United States.
Stephen J WilsonDepartment of Psychology, The Pennsylvania State University, University Park, PA, United States.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Research Training and Educational Component (Component I) p370-385P50DA036107 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FOULDS, JONATHAN, MUSCAT, JOSHUA E · 2013 to 2018
$19.5M
Training and Education Core p270-287P50DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EISSENBERG, THOMAS EVAN · 2013 to 2017
$19.2M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Random nicotine delivery: A novel intervention for smokersR21DA038775 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI FOULDS, JONATHAN, GRIGSON, PATRICIA SUE · 2014 to 2015
$432k
(PQA1) FMRI Neurofeedback and Descision-Making in Habitual Cigarette SmokersR21CA190093 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI WILSON, STEPHEN JEFFREY · 2014 to 2015
$361k
Nicotine dependence, reward sensitivity, and lapse behavior in light smokersR03DA035929 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI WILSON, STEPHEN JEFFREY · 2014 to 2015
$148k
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NCI NIH HHS R21 CA190093NIDA NIH HHS P50 DA036105NIDA NIH HHS P50 DA036107NIDA NIH HHS R03 DA035929NIDA NIH HHS R21 DA038775
6 · The paper itself

Abstract

Some individuals who try electronic cigarettes (e-cigarettes) continue to use long-term. Previous research has investigated the safety of e-cigarettes and their potential for use in smoking cessation, but comparatively little research has explored chronic or habitual e-cigarette use. In particular, the relationship between e-cigarette cues and craving is unknown. We sought to bridge this gap by developing a novel set of e-cigarette (salient) and electronic toothbrush (neutral) videos for use in cue-reactivity paradigms. Additionally, we demonstrate the utility of this approach in a pilot fMRI study of 7 experienced e-cigarette users. Participants were scanned while viewing the cue videos before and after 10min use of their own e-cigarettes (producing an 11.7ng/ml increase in plasma nicotine concentration). A significant session (pre- and post-use) by video type (salient and neutral) interaction was exhibited in many sensorimotor areas commonly activated in other cue-reactivity paradigms. We did not detect significant cue-related activity in other brain regions notable in the craving literature. Possible reasons for this discrepancy are discussed, including the importance of matching cue stimuli to participants' experiences.

Indexed as

AdultCravingCuesElectronic Nicotine Delivery SystemsFemaleHumansMagnetic Resonance ImagingMaleNicotinePilot ProjectsSelf ReportSmokingSmoking CessationSubstance Withdrawal SyndromeVapingNicotineCravingCueE-cigaretteE-cigsfMRIStimulus

Identifiers

PMID26478134
PMCPMC4842166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.