Evidence map›Paper›PMID 26477820›Full record

ArticleCritical care (London, England)2015

Associations between single nucleotide polymorphisms in the FAS pathway and acute kidney injury.

Pavan Bhatraju, Christine Hsu, Paramita Mukherjee, Bradford J Glavan, Amber Burt, Carmen Mikacenic, Jonathan Himmelfarb, Mark Wurfel

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00281268 (Fluids and Catheters Treatment Trial), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00281268 phase3completednot on this map

Fluids and Catheters Treatment Trial (FACTT) - ARDS Clinical Research Network

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)ConditionsAcute Respiratory Distress Syndrome, Lung DiseasesArmspulmonary artery catheter, central venous catheter, fluid management
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Diuretics for preventing and treating acute kidney injury.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Identification of prognostic biomarkers for antibiotic associated nephrotoxicity in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024
    Article
  3. Article
  4. Article
  5. NFκB and Kidney Injury.Frontiers in immunology · 2019
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Pavan BhatrajuPulmonary Critical Care Medicine, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 359640, Seattle, WA, 98104, USA. Bhatraju@uw.edu.
Christine HsuKidney Research Institute, Division of Nephrology, University of Washington, Seattle, WA, USA. cwhsu8@uw.edu.
Paramita MukherjeeKidney Research Institute, Division of Nephrology, University of Washington, Seattle, WA, USA. paramit_mukherj@hotmail.com.
Bradford J GlavanPulmonary Critical Care and Sleep Medicine, The Oregon Clinic, Portland, OR, USA. bglavan@orclinic.com.
Amber BurtBiostatistics University of Washington, Seattle, WA, USA. aaburt@uw.edu.
Carmen MikacenicPulmonary and Critical Care, University of Washington, Seattle, WA, USA. cmikacen@uw.edu.
Jonathan HimmelfarbKidney Research Institute, Division of Nephrology, University of Washington, Seattle, WA, USA. himmej@uw.edu.
Mark WurfelPulmonary and Critical Care, University of Washington, Seattle, WA, USA. mwurfel@uw.edu.
University of Washington · USHarborview Medical Center · USOregon Clinic · USSeattle University · US

Funding

RESEARCH TRAINING IN RENAL DISEASET32DK007467 · NIDDK · UNIVERSITY OF WASHINGTON · PI BANSAL, NISHA, KESTENBAUM, BRYAN R · 1986 to 2023
$5.1M
NIDDK NIH HHS T32 DK007467NIDDK NIH HHS T32DK007467-29
6 · The paper itself

Abstract

introductionTo determine whether single nucleotide polymorphisms (SNPs) in FAS and related genes are associated with acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS).

methodsWe studied 401 (Caucasian N = 310 and African-American N = 91) patients aged ≥ 13 years with ALI who enrolled in the Fluid and Catheter Treatment Trial (FACTT) between 2000 and 2005 from 20 North American centers. We genotyped 367 SNPs in 45 genes of the Fas/Fas ligand pathway to identify associations between SNPs in Fas pathway genes and the development of AKI by day 2 after enrollment in FACTT, adapting Acute Kidney Injury Network (AKIN) criteria. Written informed consent was obtained from participants or legally authorized surrogates in the original FACTT study and available to use for secondary analysis.

resultsIn Caucasian patients, we identified associations between two SNPs and the incidence of AKI (stage 1 and above): rs1050851 and rs2233417; both are found within the gene for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA). For rs1050851 and rs2233417, the odds ratios (ORs) were 2.34 (95 % confidence interval (CI) = 1.58-3.46, p = 1.06 × 10(-5), FDR = 0.003) and 2.46 (CI = 1.61-3.76, p = 1.81 × 10(-5), FDR = 0.003) for each minor allele, respectively. The associations were stronger still for AKIN stage 2-3 with respective ORs 4.00 (CI = 2.10-7.62, p = 1.05 × 10(-5), FDR = 0.003) and 4.03 (CI = 2.09-7.77, p = 1.88 × 10(-5), FDR = 0.003) for each minor allele homozygote. We observed no significant association between these SNPs and AKI in the smaller subset of African Americans.

conclusionIn Caucasian patients with ALI, the presence of minor alleles in two SNPs in NFKBIA was strongly associated with the development of AKI.

trial registrationNCT00281268 . Registered 20/01/2006.

Indexed as

Polymorphism, Single NucleotideAcute Kidney InjuryAllelesBlack or African AmericanFas Ligand ProteinFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansI-kappa B ProteinsMaleMiddle AgedNF-KappaB Inhibitor alphaRespiratory Distress SyndromeSignal TransductionWhite PeopleFas Ligand ProteinI-kappa B ProteinsNF-KappaB Inhibitor alphaNFKBIA protein, human

Identifiers

PMID26477820
PMCPMC4610046
OpenAlexW1903966781

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.