Evidence map›Paper›PMID 26477791›Full record

ArticleAutism research : official journal of the International Society for Autism Research2016

Prolonged auditory brainstem responses in infants with autism.

Oren Miron, Daphne Ari-Even Roth, Lidia V Gabis, Yael Henkin, Shahar Shefer, Ilan Dinstein, Ronny Geva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review.Autism research : official journal of the International Society for Autism Research · 2018
    Pooled it
  3. Auditory brainstem response in infants and children with autism spectrum disorder: A meta-analysis of wave V.Autism research : official journal of the International Society for Autism Research · 2018
    Pooled it
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  17. Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2021
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  18. Article
  19. GABAFrontiers in integrative neuroscience · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Oren MironDepartment of Psychology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Daphne Ari-Even RothHearing, Speech and Language Center, Sheba Medical Center, Ramat Gan, Israel.
Lidia V GabisThe Weinberg Child Development Center, Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Yael HenkinHearing, Speech and Language Center, Sheba Medical Center, Ramat Gan, Israel.
Shahar SheferThe Weinberg Child Development Center, Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Ilan DinsteinDepartment of Psychology, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Ronny GevaDevelopmental Neuropsychology Laboratory, The Gonda Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.ORCID 0000-0002-5724-2153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous studies have attempted to identify early physiological abnormalities in infants and toddlers who later develop autism spectrum disorder (ASD). One potential measure of early neurophysiology is the auditory brainstem response (ABR), which has been reported to exhibit prolonged latencies in children with ASD. We examined whether prolonged ABR latencies appear in infancy, before the onset of ASD symptoms, and irrespective of hearing thresholds. To determine how early in development these differences appear, we retrospectively examined clinical ABR recordings of infants who were later diagnosed with ASD. Of the 118 children in the participant pool, 48 were excluded due to elevated ABR thresholds, genetic aberrations, or old testing age, leaving a sample of 70 children: 30 of which were tested at 0-3 months, and 40 were tested at toddlerhood (1.5-3.5 years). In the infant group, the ABR wave-V was significantly prolonged in those who later developed ASD as compared with case-matched controls (n = 30). Classification of infants who later developed ASD and case-matched controls using this measure enabled accurate identification of ASD infants with 80% specificity and 70% sensitivity. In the group of toddlers with ASD, absolute and interpeak latencies were prolonged compared to clinical norms. Findings indicate that ABR latencies are significantly prolonged in infants who are later diagnosed with ASD irrespective of their hearing thresholds; suggesting that abnormal responses might be detected soon after birth. Further research is needed to determine if ABR might be a valid marker for ASD risk. Autism Res 2016, 9: 689-695. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.

Indexed as

Auditory ThresholdAutistic DisorderCase-Control StudiesChild, PreschoolEvoked Potentials, Auditory, Brain StemFemaleHumansInfantMaleSensitivity and Specificityauditory brainstem responseautism spectrum disorderhearing

Identifiers

PMID26477791
PMCPMC5057307

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.