ArticleNeuroImage2016
The absolute CBF response to activation is preserved during elevated perfusion: Implications for neurovascular coupling measures.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- CONature communications · 2022Pooled it
- Metabolite concentration changes associated with positive and negative BOLD responses in the human visual cortex: A functional MRS study at 7 Tesla.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Regional BOLD variability reflects microstructural maturation and neuronal ensheathment in the preterm infant cortex.Nature communications · 2026Article
- Characterizing vascular function in mouse models of Alzheimer's disease, atherosclerosis, and mixed Alzheimer's and atherosclerosis.Neurophotonics · 2025Article
- In search of a marker of altered cerebrovascular function in hypertension: Analysis of the fractional amplitude of low-frequency fluctuations in UK Biobank resting state fMRI data.Cerebral circulation - cognition and behavior · 2024Article
- Assessment of brainstem function and haemodynamics by MRI: challenges and clinical prospects.The British journal of radiology · 2023Review
- Brain structure-function coupling associated with cognitive impairment in cerebral small vessel disease.Frontiers in neuroscience · 2023Review
- Changes in hemodynamic response function components reveal specific changes in neurovascular coupling in type 2 diabetes.Frontiers in physiology · 2022Article
- The Spatiotemporal Dynamics of Cerebral Autoregulation in Functional Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Article
- Investigating mechanisms of fast BOLD responses: The effects of stimulus intensity and of spatial heterogeneity of hemodynamics.NeuroImage · 2021Article
- Effects of changes in end-tidal POPhysiological reports · 2021Article
- The effects of age on resting-state BOLD signal variability is explained by cardiovascular and cerebrovascular factors.Psychophysiology · 2021Article
- Developmental patterns of CBF and BOLD responses to visual stimulus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Measuring Arterial Pulsatility With Dynamic Inflow Magnitude Contrast.Frontiers in neuroscience · 2021Article
- Article
- Measurement of CMROJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Dynamics of the cerebral blood flow response to brief neural activity in human visual cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Elevation of intracranial pressure affects the relationship between hemoglobin concentration and neuronal activation in human somatosensory cortex.Human brain mapping · 2020Article
- BOLD fMRI and hemodynamic responses to somatosensory stimulation in anesthetized mice: spontaneous breathing vs. mechanical ventilation.NMR in biomedicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) techniques in which the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) response to a neural stimulus are measured, can be used to estimate the fractional increase in the cerebral metabolic rate of oxygen consumption (CMRO2) that accompanies evoked neural activity. A measure of neurovascular coupling is obtained from the ratio of fractional CBF and CMRO2 responses, defined as n, with the implicit assumption that relative rather than absolute changes in CBF and CMRO2 adequately characterise the flow-metabolism response to neural activity. The coupling parameter n is important in terms of its effect on the BOLD response, and as potential insight into the flow-metabolism relationship in both normal and pathological brain function. In 10 healthy human subjects, BOLD and CBF responses were measured to test the effect of baseline perfusion (modulated by a hypercapnia challenge) on the coupling parameter n during graded visual stimulation. A dual-echo pulsed arterial spin labelling (PASL) sequence provided absolute quantification of CBF in baseline and active states as well as relative BOLD signal changes, which were used to estimate CMRO2 responses to the graded visual stimulus. The absolute CBF response to the visual stimuli were constant across different baseline CBF levels, meaning the fractional CBF responses were reduced at the hyperperfused baseline state. For the graded visual stimuli, values of n were significantly reduced during hypercapnia induced hyperperfusion. Assuming the evoked neural responses to the visual stimuli are the same for both baseline CBF states, this result has implications for fMRI studies that aim to measure neurovascular coupling using relative changes in CBF. The coupling parameter n is sensitive to baseline CBF, which would confound its interpretation in fMRI studies where there may be significant differences in baseline perfusion between groups. The absolute change in CBF, as opposed to the change relative to baseline, may more closely match the underlying increase in neural activity in response to a stimulus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.