ArticleNature communications2015
An Xist-activating antisense RNA required for X-chromosome inactivation.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist-Tsix locus.Nature communications · 2025Article
- Multifaceted role of CTCF in X-chromosome inactivation.Chromosoma · 2024Review
- Molecular insights into regulatory RNAs in the cellular machinery.Experimental & molecular medicine · 2024Review
- Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogramming.Life science alliance · 2024Article
- Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A.Cellular and molecular life sciences : CMLS · 2024Article
- Review
- Single-cell analysis reveals X upregulation is not global in pre-gastrulation embryos.iScience · 2022Article
- The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.Cold Spring Harbor perspectives in biology · 2022Review
- Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.Nature communications · 2022Article
- Review
- Developmental Acquisition ofGenes · 2021Review
- Semicoordinated allelic-bursting shape dynamic random monoallelic expression in pregastrulation embryos.iScience · 2021Article
- lncRNA-Xist/miR-101-3p/KLF6/C/EBPα axis promotes TAM polarization to regulate cancer cell proliferation and migration.Molecular therapy. Nucleic acids · 2021Article
- DNA methylation and functional characterization of the XIST gene duringEpigenetics · 2019Article
- Identification of a novel antisense RNA that regulates growth hormone receptor expression in chickens.RNA biology · 2019Article
- Article
- Experimental Analysis of Imprinted Mouse X-Chromosome Inactivation.Methods in molecular biology (Clifton, N.J.) · 2018Article
- What makes the maternal X chromosome resistant to undergoing imprinted X inactivation?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Sm-Like Protein-Mediated RNA Metabolism Is Required for Heat Stress Tolerance in Arabidopsis.Frontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The transcriptional imbalance due to the difference in the number of X chromosomes between male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptional silencing of one of the two X chromosomes in females. The X-linked Xist long non-coding RNA functions as an X inactivation master regulator; Xist is selectively upregulated from the prospective inactive X chromosome and is required in cis for X inactivation. Here we discover an Xist antisense long non-coding RNA, XistAR (Xist Activating RNA), which is encoded within exon 1 of the mouse Xist gene and is transcribed only from the inactive X chromosome. Selective truncation of XistAR, while sparing the overlapping Xist RNA, leads to a deficiency in Xist RNA expression in cis during the initiation of X inactivation. Thus, the Xist gene carries within its coding sequence an antisense RNA that drives Xist expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.