ArticleDepression and anxiety2016
A COMPREHENSIVE EXAMINATION OF WHITE MATTER TRACTS AND CONNECTOMETRY IN MAJOR DEPRESSIVE DISORDER.
Article in Depression and anxiety, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- White matter tracts associated with iTBS-induced heart rate deceleration and treatment response in major depressive disorder.Translational psychiatry · 2025Trial
- Cortical thickness is not associated with current depression in a clinical treatment study.Human brain mapping · 2017Trial
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- Microstructural and functional alterations of the ventral pallidum are associated with levodopa-induced dyskinesia in Parkinson's disease.European journal of neurology · 2024Article
- Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study.Nature and science of sleep · 2024Article
- Preliminary findings on the effect of childhood trauma on the functional connectivity of the anterior cingulate cortex subregions in major depressive disorder.Frontiers in psychiatry · 2023Article
- White matter connectometry in patients with disorders of consciousness revealed by 7-Tesla magnetic resonance imaging.Brain imaging and behavior · 2022Article
- Gray and white matter structural examination for diagnosis of major depressive disorder and subthreshold depression in adolescents and young adults: a preliminary radiomics analysis.BMC medical imaging · 2022Article
- White matter integrity in adolescent irritability: A preliminary study.Psychiatry research. Neuroimaging · 2022Article
- Desynchronized white matter function and structure in drug-naive first-episode major depressive disorder patients.Frontiers in psychiatry · 2022Article
- Effects of 3-month CPAP therapy on brain structure in obstructive sleep apnea: A diffusion tensor imaging study.Frontiers in neurology · 2022Article
- Reduced white matter microstructure in bipolar disorder with and without psychosis.Bipolar disorders · 2021Article
- The human dorsal hippocampal commissure: Delineating connections across the midline using multi-modal neuroimaging in major depressive disorder.Neuroimage. Reports · 2021Article
- Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder.Neural plasticity · 2021Article
- Chronic disorders of consciousness: a case report with longitudinal evaluation of disease progression using 7 T magnetic resonance imaging.BMC neurology · 2020Article
- White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group.Molecular psychiatry · 2020Article
- Examining raphe-amygdala structural connectivity as a biological predictor of SSRI response.Journal of affective disorders · 2019Article
- Multimodal imaging reveals a complex pattern of dysfunction in corticolimbic pathways in major depressive disorder.Human brain mapping · 2019Article
- Molecular connectivity disruptions in males with major depressive disorder.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Cognitive and White-Matter Compartment Models Reveal Selective Relations between Corticospinal Tract Microstructure and Simple Reaction Time.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is a debilitating disorder characterized by widespread brain abnormalities. The literature is mixed as to whether or not white matter abnormalities are associated with MDD. This study sought to examine fractional anisotropy (FA) in white matter tracts in individuals with MDD using diffusion tensor imaging (DTI).
methods139 participants with MDD and 39 healthy controls (HC) in a multisite study were included. DTI scans were acquired in 64 directions and FA was determined in the brain using four methods: region of interest (ROI), tract-based spatial statistics (TBSS), and diffusion tractography. Diffusion connectometry was used to identify white matter pathways associated with MDD.
resultsThere were no significant differences when comparing FA in MDD and HC groups using any method. In the MDD group, there was a significant relationship between depression severity and FA in the right medial orbitofrontal cortex, and between age of onset of MDD and FA in the right caudal anterior cingulate cortex using the ROI method. There was a significant relationship between age of onset and connectivity in the thalamocortical radiation, inferior longitudinal fasciculus, and cerebellar tracts using diffusion connectometry.
conclusionsThe lack of group differences in FA and connectometry analysis may result from the clinically heterogenous nature of MDD. However, the relationship between FA and depression severity may suggest a state biomarker of depression that should be investigated as a potential indicator of response. Age of onset may also be a significant clinical feature to pursue when studying white matter tracts.
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