ArticleScientific reports2015
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 127 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci.Translational psychiatry · 2021Pooled it
- Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues.Aging · 2021Pooled it
- Pleiotropy and disease interactors: the dual nature of genes linking ageing and ageing-related diseases.Biogerontology · 2026Article
- Systems genomics reveals age- and sex-dependent metabolic dysregulation fromPhysiological genomics · 2026Article
- Age effect explorer: a Shiny application to browse and visualize tissue-specific age-related gene expression changes.Bioinformatics advances · 2026Article
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- The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus data repository.Genome biology · 2025Article
- Association of the expression of 5-FU biomarkers with aging and prognosis in elderly patients with lung cancer treated with S-1 adjuvant chemotherapy: Follow-up results of the Setouchi Lung Cancer Group Study 1201.Molecular and clinical oncology · 2025Article
- Evaluating transcriptional alterations associated with ageing and developing age prediction models based on the human blood transcriptome.Biogerontology · 2025Article
- A computational framework for detecting inter-tissue gene-expression coordination changes with aging.Scientific reports · 2025Article
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- Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder.Molecular psychiatry · 2025Article
- Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk.Cell genomics · 2025Article
- Advances in the application of multi-omics analysis in skin aging.Frontiers in aging · 2025Review
- Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk.bioRxiv : the preprint server for biology · 2024Article
- An atlas of the aging mouse proteome reveals the features of age-related post-transcriptional dysregulation.Nature communications · 2024Article
- Targeted co-expression networks for the study of traits.Scientific reports · 2024Article
- The downregulation of genes encoding muscle proteins have a potential role in the development of scrotal hernia in pigs.Molecular biology reports · 2024Article
- voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues.eLife · 2024Article
- Open Genes-a new comprehensive database of human genes associated with aging and longevity.Nucleic acids research · 2024Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.2016 · Goldman, Jakob [corrected to Goldmann, Jakob]
Authors and funding
12 authors at 20 institutions in 9 countries.
Funding
Abstract
Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g., heart and lung) show much stronger "co-aging" than other tissues based on a principal component analysis. The aging gene signatures and complex disease genes show a complex overlapping pattern and only in some cases, we see that they are significantly overlapped in the tissues affected by the corresponding diseases. In summary, our analyses provide novel insights to the co-regulation of age-related gene expression in multiple tissues; it also presents a tissue-specific view of the link between aging and age-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.