Evidence map›Paper›PMID 26477442›Full record

ArticleHelicobacter2016

Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma.

Michael Y Esmail, Rebecca Bacon, Alton G Swennes, Yan Feng, Zeli Shen, AnaPatricia Garcia, Prachi Sharma, Joyce Cohen, James G Fox

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Helicobacter, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Michael Y EsmailDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Rebecca BaconDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alton G SwennesDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yan FengDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zeli ShenDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
AnaPatricia GarciaDivision of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Prachi SharmaDivision of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Joyce CohenDivision of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
James G FoxDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA.
Massachusetts Institute of Technology · USEmory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YAFFE, MICHAEL B · 1985 to 2020
$25.6M
Project 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8M
Role of Inflamation in Mouse Models of Gastric CancerR01CA093405 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, TIMOTHY CRAGIN · 2001 to 2016
$3.8M
HELIOBACTER INDUCED HEPATITIS AND TUMORIGENESISR01CA067529 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FOX, JAMES G · 1995 to 2009
$3.2M
Biomedical Research Training for Veterinary ScientistsT32OD010978 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FOX, JAMES G · 2012 to 2017
$2.2M
NCI NIH HHS P01 CA028842NCI NIH HHS R01 CA067529NCI NIH HHS R01 CA093405NIEHS NIH HHS P30 ES002109NIH HHS P51 OD011132NIH HHS T32 OD010978
6 · The paper itself

Abstract

backgroundOf all human cancers, gastric carcinoma is the one of the leading causes of death. Helicobacter pylori is considered a major etiologic agent of this disease. Spontaneously occurring gastric carcinoma is a rare diagnosis in nonhuman primates. A 2011 case report documented a high incidence of gastric adenocarcinoma in a closed colony of captive sooty mangabeys (Cercebus atys). However, H. pylori infection was not detected in these animals. MATERIALS AND

methodsIn this study, using archived formalin-fixed, paraffin-embedded stomach sections of these animals alternative methodologies were used to identify H. pylori and other non-H. pylori Helicobacter species. In addition, two additional cases of sooty mangabeys with metastatic gastric carcinoma are characterized.

resultsUsing fluorescent in situ hybridization, we identified gastric H. suis in 75% of archived and new gastric carcinoma cases. In the two newly reported cases, H. suis and a novel Helicobacter species were detected via PCR and sequence analysis of the 16S rRNA gene. H. pylori was not identified in any of the gastric carcinoma cases via FISH and/or PCR and sequence analysis of Helicobacter spp. in DNA from of available tissues.

conclusionsThis report is the first to characterize Helicobacter species infection in spontaneous gastric carcinoma with metastatic potential in nonhuman primates.

Indexed as

AdenocarcinomaAnimalsCercocebus atysFemaleHelicobacterHelicobacter InfectionsIn Situ Hybridization, FluorescenceMaleMonkey DiseasesPhylogenyPolymerase Chain ReactionSequence Analysis, DNAStomachStomach NeoplasmsHelicobactermetastatic gastric adenocarcinomasooty mangabeys

Identifiers

PMID26477442
PMCPMC4837085
OpenAlexW1943298948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.