ArticleScientific reports2015
Combination of six enzymes of a marine Novosphingobium converts the stereoisomers of β-O-4 lignin model dimers into the respective monomers.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Efficient Lignin Dissolution and Enzymatic Depolymerization in Ethylene Glycol-Based Deep Eutectic Solvent Mixtures: Integrated Experimental and Molecular Dynamics Study.The journal of physical chemistry. B · 2026Article
- Strategies Toward Synthesis and Conversion of Lignin Model Compounds.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- The etherase system of Novosphingobium sp. MBES04 functions as a sensor of lignin fragments through phenylpropanone production to induce specific transcriptional responses.Environmental microbiology reports · 2024Article
- Isolation and characterization of microorganisms capable of cleaving the ether bond of 2-phenoxyacetophenone.Scientific reports · 2022Article
- The role of oxygen in stimulating methane production in wetlands.Global change biology · 2021Article
- Microbial bioprospecting for lignocellulose degradation at a unique Greek environment.Heliyon · 2021Article
- Comparison of the Intestinal Microbiota During the Different Growth Stages of Red Swamp Crayfish (Frontiers in microbiology · 2021Article
- Roles of two glutathione S-transferases in the final step of the β-aryl ether cleavage pathway in Sphingobium sp. strain SYK-6.Scientific reports · 2020Article
- Enzymatic removal of inhibitory compounds from lignocellulosic hydrolysates for biomass to bioproducts applications.World journal of microbiology & biotechnology · 2020Review
- Functional genomic analysis of bacterial lignin degraders: diversity in mechanisms of lignin oxidation and metabolism.Applied microbiology and biotechnology · 2020Review
- Database Mining for Novel Bacterial β-Etherases, Glutathione-Dependent Lignin-Degrading Enzymes.Applied and environmental microbiology · 2020Article
- Complete Genome Sequence of Serratia quinivorans Strain 124R, a Facultative Anaerobe Isolated on Organosolv Lignin as a Sole Carbon Source.Microbiology resource announcements · 2019Article
- A heterodimeric glutathioneThe Journal of biological chemistry · 2019Article
- Delineation of the functional and structural properties of the glutathione transferase family from the plant pathogen Erwinia carotovora.Functional & integrative genomics · 2019Article
- Complete Genome Sequence of Sphingobium sp. Strain YG1, a Lignin Model Dimer-Metabolizing Bacterium Isolated from Sediment in Kagoshima Bay, Japan.Genome announcements · 2018Article
- Article
- Bacterial Catabolism of β-Hydroxypropiovanillone and β-Hydroxypropiosyringone Produced in the Reductive Cleavage of Arylglycerol-β-Aryl Ether in Lignin.Applied and environmental microbiology · 2018Article
- Efficient, environmentally-friendly and specific valorization of lignin: promising role of non-radical lignolytic enzymes.World journal of microbiology & biotechnology · 2017Review
- Enzymatic Specific Production and Chemical Functionalization of Phenylpropanone Platform Monomers from Lignin.ChemSusChem · 2017Article
- Bacterial plasmid-mediated quinolone resistance genes in aquatic environments in China.Scientific reports · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Lignin, an aromatic polymer of phenylpropane units joined predominantly by β-O-4 linkages, is the second most abundant biomass component on Earth. Despite the continuous discharge of terrestrially produced lignin into marine environments, few studies have examined lignin degradation by marine microorganisms. Here, we screened marine isolates for β-O-4 cleavage activity and determined the genes responsible for this enzymatic activity in one positive isolate. Novosphingobium sp. strain MBES04 converted all four stereoisomers of guaiacylglycerol-β-guaiacyl ether (GGGE), a structural mimic of lignin, to guaiacylhydroxypropanone as an end metabolite in three steps involving six enzymes, including a newly identified Nu-class glutathione-S-transferase (GST). In silico searches of the strain MBES04 genome revealed that four GGGE-metabolizing GST genes were arranged in a cluster. Transcriptome analysis demonstrated that the lignin model compounds GGGE and (2-methoxyphenoxy)hydroxypropiovanillone (MPHPV) enhanced the expression of genes in involved in energy metabolism, including aromatic-monomer assimilation, and evoked defense responses typically expressed upon exposure to toxic compounds. The findings from this study provide insight into previously unidentified bacterial enzymatic systems and the physiological acclimation of microbes associated with the biological transformation of lignin-containing materials in marine environments.
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