ReviewEuropean journal of nutrition2016
A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance.
Review in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Fructose-Induced Impairment of Liver and Skeletal Muscle Metabolism Is Prevented by Administration of Shouchella clausii Spores by Preserving Mitochondrial Function and Insulin Sensitivity.Molecular nutrition & food research · 2025Article
- Mitochondria at the Crossroads: Linking the Mediterranean Diet to Metabolic Health and Non-Pharmacological Approaches to NAFLD.Nutrients · 2025Review
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- Mitochondria as a target for exercise-mitigated type 2 diabetes.Journal of molecular histology · 2023Review
- Recent Overview of Potent Antioxidant Activity of Coordination Compounds.Antioxidants (Basel, Switzerland) · 2023Review
- Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway.Acta biochimica et biophysica Sinica · 2022Article
- Article
- Mitochondrial dysfunction in skeletal muscle contributes to the development of acute insulin resistance in mice.Journal of cachexia, sarcopenia and muscle · 2021Article
- Blueberry Counteracts Prediabetes in a Hypercaloric Diet-Induced Rat Model and Rescues Hepatic Mitochondrial Bioenergetics.Nutrients · 2021Article
- Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes.Molecules (Basel, Switzerland) · 2021Review
- Prolonged Changes in Hepatic Mitochondrial Activity and Insulin Sensitivity by High Fructose Intake in Adolescent Rats.Nutrients · 2021Article
- Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes.Nature communications · 2021Article
- A mixture of mulberry and silk amino acids protected against D-galactosamine induced acute liver damage by attenuating oxidative stress and inflammation in HepG2 cells and rats.Experimental and therapeutic medicine · 2020Article
- Oxidative stress, nutritional antioxidants and beyond.Science China. Life sciences · 2020Review
- Early Hepatic Oxidative Stress and Mitochondrial Changes Following Western Diet in Middle Aged Rats.Nutrients · 2019Article
- Adipose Tissue Composition in Obesity and After Bariatric Surgery.Obesity surgery · 2019Review
- Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study.Journal of the American Heart Association · 2019Article
- Mitophagy in Hepatic Insulin Resistance: Therapeutic Potential and Concerns.Frontiers in pharmacology · 2019Review
- Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.Nature communications · 2018Article
- Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IRInternational journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMitochondria are the main cellular sites devoted to ATP production and lipid oxidation. Therefore, the mitochondrial dysfunction could be an important determinant of cellular fate of circulating lipids, that accumulate in the cytoplasm, if they are not oxidized. The ectopic fat accumulation is associated with the development of insulin resistance, and a link between mitochondrial dysfunction and insulin resistance has been proposed.
methodsRecent data on the possible link existing between mitochondrial dysfunction in the liver and diet induced obesity will be summarized, focusing on the three factors that affect the mitochondrial oxidation of metabolic fuels, i.e. organelle number, organelle activity, and energetic efficiency of the mitochondrial machinery in synthesizing ATP. Search in PubMed relevant articles from 2003 to 2014 was conducted, by using query “liver mitochondria and obesity” “hepatic mitochondria and obesity” “liver mitochondria and high fat diet” and “hepatic mitochondria and high fat diet” and including related articles by the same groups.
resultsSeveral works, by using different physiological approaches, have dealt with alteration in mitochondrial function in obesity and diabetes. Most results show that hepatic mitochondrial function is impaired in models of obesity and insulin resistance induced by high-fat or highfructose feeding.
conclusionsSince mitochondria are the main producers of both cellular energy and free radicals, dysfunctional mitochondria could play an important role in the development of insulin resistance and ectopic fat storage in the liver, thus supporting the emerging idea that mitochondrial dysfunction is closely related to the development of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.
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