ArticleBiological psychiatry2016
Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders.
Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.American journal of human genetics · 2019Pooled it
- GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium.Molecular psychiatry · 2017Pooled it
- Cognitive impairment preceding the onset of the first psychosis episode in schizophrenia.Molecular psychiatry · 2026Review
- Genome-wide association study of positive and negative affect reveals shared genetic architecture and a potential causal relationship with cognition.Scientific reports · 2026Article
- Disorder-Specific Genetic Effects Drive the Associations Between Psychopathology and Cognitive Functioning.Biological psychiatry global open science · 2026Article
- An analysis of the mediating influence of depression on the association between early-life caregiver relationships and cognitive function: a cohort study based on the CHARLS database.Frontiers in psychiatry · 2025Article
- Studying the relationship between intelligence quotient and schizophrenia polygenic scores in a family design with first-episode psychosis population.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Vertical pleiotropy explains the heritability of social science traits.The Behavioral and brain sciences · 2023Article
- Alzheimer's genetic risk effects on cerebral blood flow across the lifespan are proximal to gene expression.Neurobiology of aging · 2022Article
- Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology.Nature communications · 2022Article
- Age-dependent patterns of schizophrenia genetic risk affect cognition.Schizophrenia research · 2022Article
- Can EEG Correlates Predict Treatment Efficacy in Children with Overlapping ASD and SLI Symptoms: A Case Report.Diagnostics (Basel, Switzerland) · 2022Article
- Genomic selection signatures in autism spectrum disorder identifies cognitive genomic tradeoff and its relevance in paradoxical phenotypes of deficits versus potentialities.Scientific reports · 2021Article
- Intelligence, health and death.Nature human behaviour · 2021Review
- Evidence for specificity of polygenic contributions to attainment in English, maths and science during adolescence.Scientific reports · 2021Article
- Multimodal hippocampal and amygdala subfield volumetry in polygenic risk for Alzheimer's disease.Neurobiology of aging · 2021Article
- Genetic risk for Alzheimer's disease, cognition, and mild behavioral impairment in healthy older adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Familial aggregation analysis of cognitive performance in early-onset bipolar disorder.European child & adolescent psychiatry · 2020Article
- Polygenic predictors of age-related decline in cognitive ability.Molecular psychiatry · 2020Article
- Polygenic risk and pleiotropy in neurodegenerative diseases.Neurobiology of disease · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGeneral cognitive function predicts psychiatric illness across the life course. This study examines the role of pleiotropy in explaining the link between cognitive function and psychiatric disorder.
methodsWe used two large genome-wide association study data sets on cognitive function-one from older age, n = 53,949, and one from childhood, n = 12,441. We also used genome-wide association study data on educational attainment, n = 95,427, to examine the validity of its use as a proxy phenotype for cognitive function. Using a new method, linkage disequilibrium regression, we derived genetic correlations, free from the confounding of clinical state between psychiatric illness and cognitive function.
resultsWe found a genetic correlation of .711 (p = 2.26e-12) across the life course for general cognitive function. We also showed a positive genetic correlation between autism spectrum disorder and cognitive function in childhood (rg = .360, p = .0009) and for educational attainment (rg = .322, p = 1.37e-5) but not in older age. In schizophrenia, we found a negative genetic correlation between older age cognitive function (rg = -.231, p = 3.81e-12) but not in childhood or for educational attainment. For Alzheimer's disease, we found negative genetic correlations with childhood cognitive function (rg = -.341, p = .001), educational attainment (rg = -.324, p = 1.15e-5), and with older age cognitive function (rg = -.324, p = 1.78e-5).
conclusionsThe pleiotropy exhibited between cognitive function and psychiatric disorders changed across the life course. These age-dependent associations might explain why negative selection has not removed variants causally associated with autism spectrum disorder or schizophrenia.
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