Evidence map›Paper›PMID 26476352›Full record

ReviewCurrent opinion in virology2015

Animal models of tumorigenic herpesviruses--an update.

Dirk P Dittmer, Blossom Damania, Sang-Hoon Sin

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Animal models of human herpesvirus infection.Animal models and experimental medicine · 2025
    Review
  3. Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dirk P DittmerLineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA. Electronic address: ddittmer@med.unc.edu.
Blossom DamaniaLineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.
Sang-Hoon SinLineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.
Johns Hopkins University Center for AIDS Research

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
ART Modulation of Viral Pathogenesis in Oral EpitheliaR01DE018304 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DITTMER, DIRK P · 2007 to 2025
$6.9M
Targeted Therapies for HIV-Associated Kaposi Sarcoma and LymphomaR01CA163217 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, Dirk P Dittmer · 2011 to 2026
$5.5M
Targeting the epigenome of gammaherpesviruses in oral diseaseR01DE023946 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, DITTMER, DIRK P · 2013 to 2017
$2.3M
(PQD2) Why is Endemic Burkitt Lymphoma Curable with Single Agent Chemotherapy?R21CA180097 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DITTMER, DIRK P · 2013 to 2014
$358k
NCI NIH HHS CA019014NCI NIH HHS CA163217NCI NIH HHS CA180097NCI NIH HHS P01 CA019014NCI NIH HHS R01 CA163217NCI NIH HHS R21 CA180097NIDCR NIH HHS DE023946NIDCR NIH HHS R01 DE018304NIDCR NIH HHS R01 DE023946
6 · The paper itself

Abstract

Any one model system, be it culture or animal, only recapitulates one aspect of the viral life cycle in the human host. By providing recent examples of animal models for Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus, we would argue that multiple animal models are needed to gain a comprehensive understanding of the pathogenesis associated with human oncogenic herpesviruses. Transgenic mice, homologous animal herpesviruses, and tumorgraft and humanized mouse models all complement each other in the study of viral pathogenesis. The use of animal model systems facilitates the exploration of novel anti-viral and anti-cancer treatment modalities for diseases associated with oncogenic herpesviruses.

Indexed as

CarcinogenesisDisease Models, AnimalHost-Pathogen InteractionsAnimalsHerpesviridaeHerpesviridae InfectionsHumansMiceOncogenic Viruses

Identifiers

PMID26476352
PMCPMC4628858
OpenAlexW1831601919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.