ArticleeLife2015
Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation.Frontiers in cellular neuroscience · 2026Review
- Neurodevelopmental abnormalities underlying behavioral deficits in a model of pediatric obstructive sleep apnea.Experimental neurology · 2025Article
- Impact of hypoxia on the hippocampus: A review.Medicine · 2025Review
- Article
- The Brain at High Altitude: From Molecular Signaling to Cognitive Performance.International journal of molecular sciences · 2023Review
- The Long-Term Neuroprotective Effect of the Endocannabinoid 2-AG and Modulation of the SGZ's Neurogenic Response after Neonatal Hypoxia-Ischemia.Pharmaceutics · 2023Article
- Induction of Oxidative Stress and Alteration of Synaptic Gene Expression in Newborn Hippocampal Granule Cells after Developmental Exposure to Aroclor 1254.Neuroendocrinology · 2023Article
- Hyperthermia accelerates neuronal loss differently between the hippocampal CA1 and CA2/3 through different HIF‑1α expression after transient ischemia in gerbils.International journal of molecular medicine · 2022Article
- Neurogenesis Is Reduced at 48 h in the Subventricular Zone Independent of Cell Death in a Piglet Model of Perinatal Hypoxia-Ischemia.Frontiers in pediatrics · 2022Article
- The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation.CNS neuroscience & therapeutics · 2021Review
- Hippocampal neurons respond to brain activity with functional hypoxia.Molecular psychiatry · 2021Article
- Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1.Nature aging · 2021Article
- CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge.International journal of molecular sciences · 2021Article
- Stage-dependent effects of intermittent hypoxia influence the outcome of hippocampal adult neurogenesis.Scientific reports · 2021Article
- Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome.JCI insight · 2019Article
- Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.Journal of neurotrauma · 2019Article
- Intermittent Hypoxia Disrupts Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Retinoic Acid Is Required for Neural Stem and Progenitor Cell Proliferation in the Adult Hippocampus.Stem cell reports · 2018Article
- Presynaptic gain control by endogenous cotransmission of dopamine and GABA in the olfactory bulb.Journal of neurophysiology · 2017Article
- Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction.The Journal of biological chemistry · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The majority of adult hippocampal newborn cells die during early differentiation from intermediate progenitors (IPCs) to immature neurons. Neural stem cells in vivo are located in a relative hypoxic environment, and hypoxia enhances their survival, proliferation and stemness in vitro. Thus, we hypothesized that migration of IPCs away from hypoxic zones within the SGZ might result in oxidative damage, thus triggering cell death. Hypoxic niches were observed along the SGZ, composed of adult NSCs and early IPCs, and oxidative byproducts were present in adjacent late IPCs and neuroblasts. Stabilizing hypoxia inducible factor-1α with dimethyloxallyl glycine increased early survival, but not proliferation or differentiation, in neurospheres in vitro and in newly born SGZ cells in vivo. Rescue experiments in Bax(fl/fl) mutants supported these results. We propose that localized hypoxia within the SGZ contributes to the neurogenic microenvironment and determines the early, activity-independent survival of adult hippocampal newborn cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.