ReviewCurrent opinion in plant biology2015
Regulation of the plasma membrane proton pump (H(+)-ATPase) by phosphorylation.
Review in Current opinion in plant biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 199 citations in OpenAlex.
- Photo-Modulated Proton Transport in Merocyanine Metastable-State Photoacid Based Polymers.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Spatiotemporal dynamics of AHA2 reveal that RALF1 induces its endocytosis and vacuolar degradation.Plant communications · 2025Article
- TCP3-mediated regulation of cell expansion in Arabidopsis thaliana.The New phytologist · 2025Article
- bra-miR9569 Targets thePlants (Basel, Switzerland) · 2025Article
- Cellular pH homeostasis shapes root system architecture by modulating auxin-mediated developmental responses.Plant physiology · 2025Article
- Silicon-Mediated Mitigation of Salt Stress in Maize Plants.Plant-environment interactions (Hoboken, N.J.) · 2025Article
- Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity.Molecular plant · 2025Article
- Poltergeist-Like 2 (PLL2)-dependent activation of herbivore defence distinguishes systemin from other immune signalling pathways.Nature plants · 2025Article
- Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling.Cell discovery · 2025Article
- FERONIA signaling maintains cell wall integrity during brassinosteroid-induced cell expansion in Arabidopsis.Molecular plant · 2025Article
- Molecular tipping points in plant cell surface HQuantitative plant biology · 2025Review
- Transcriptomic insights into arabinogalactan protein mechanism of action in galactosyltransferase octuple mutants.Frontiers in plant science · 2025Article
- Fast and simple fluorometric measurement of phloem loading exposes auxin-dependent regulation of Arabidopsis sucrose transporter AtSUC2.The Plant journal : for cell and molecular biology · 2024Article
- The role of CBL-CIPK signaling in plant responses to biotic and abiotic stresses.Plant molecular biology · 2024Review
- Structure and growth of plant cell walls.Nature reviews. Molecular cell biology · 2024Review
- Phosphoregulation in the N-terminus of NRT2.1 affects nitrate uptake by controlling the interaction of NRT2.1 with NAR2.1 and kinase HPCAL1 in Arabidopsis.Journal of experimental botany · 2024Article
- Light-induced stomatal opening requires phosphorylation of the C-terminal autoinhibitory domain of plasma membrane HNature communications · 2024Article
- Phosphorylation of plasma membrane HNature communications · 2024Article
- Automated Real-Time Monitoring of Extracellular pH to Assess Early Plant Defense Signaling.Methods in molecular biology (Clifton, N.J.) · 2024Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In plants and fungi, energetics at the plasma membrane is provided by a large protonmotive force (PMF) generated by the family of P-type ATPases specialized for proton transport (commonly called PM H(+)-ATPases or, in Arabidopsis, AHAs for Arabidopsis H(+)-ATPases). Studies have demonstrated that this 100-kDa protein is essential for plant growth and development. Posttranslational modifications of the H(+)-ATPase play crucial roles in its regulation. Phosphorylation of several Thr and Ser residues within the carboxy terminal regulatory domain composed of ∼100 amino acids change in response to environmental stimuli, endogenous hormones, and nutrient conditions. Recently developed mass spectrometric technologies provide a means to carefully quantify these changes in H(+)-ATPase phosphorylation at the different sites. These chemical modifications can then be genetically tested in planta by complementing the loss-of-function aha mutants with phosphomimetic mutations. Interestingly, recent data suggest that phosphatase-mediated changes in PM H(+)-ATPase phosphorylation are important in mediating auxin-regulated growth. Thus, as with another hormone (abscisic acid), dephosphorylation by phosphatases, rather than kinase mediated phosphorylation, may be an important focal point for regulation during plant signal transduction. Although interactions with other proteins have also been implicated in ATPase regulation, the very hydrophobic nature and high concentration of this polytopic protein presents special challenges in evaluating the biological significance of these interactions. Only by combining biochemical and genetic experiments can we attempt to meet these challenges to understand the essential molecular details by which this protein functions in planta.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.