ArticleThe Plant cell2015
CYP76C1 (Cytochrome P450)-Mediated Linalool Metabolism and the Formation of Volatile and Soluble Linalool Oxides in Arabidopsis Flowers: A Strategy for Defense against Floral Antagonists.
Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 110 citations in OpenAlex.
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- Resilience of floral scent emission after florivory.Plant biology (Stuttgart, Germany) · 2026Article
- Floral fragrance in sweet osmanthus majorly repels pollen feeders.Science China. Life sciences · 2026Article
- A multivariate Bayesian modeling strategy coupled with QTL analysis reveals genetic loci linking important sensory wine quality attributes with their corresponding wine aroma compounds.Frontiers in plant science · 2026Article
- A balance between glycitein and glyceollins governed by isoflavone 6-hydroxylase confers soybean resistance toProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Odorant ReceptorInsects · 2025Article
- Tuning Nanofibrous Sensor Performance in Selective Detection of B-VOCs by MIP-NP Loading.Nanomaterials (Basel, Switzerland) · 2025Article
- Genome-wide characterization of the cytochrome P450 gene family in Solanum melongena and functional analysis of SmCYP82C1 under cold stress.BMC plant biology · 2025Article
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- Genome-wide identification and expression analyses of CYP450 genes in Chrysanthemum indicum.BMC genomics · 2025Article
- Unraveling the trisubstrate-triproduct reaction mechanisms of wine grape VvCYP76F14 to improve wine bouquet.Food chemistry · 2025Article
- Loss-of-function variants of CYP706A3 in two natural accessions of Arabidopsis thaliana increase floral sesquiterpene emission.BMC plant biology · 2025Article
- From Leaves to Reproductive Organs: Chemodiversity and Chemophenetics of Essential Oils as Important Tools to EvaluatePlants (Basel, Switzerland) · 2024Article
- Site-Directed Mutagenesis of VvCYP76F14 (Cytochrome P450) Unveils Its Potential for Selection in Wine Grape Varieties Linked to the Development of Wine Bouquet.Journal of agricultural and food chemistry · 2024Article
- Floral Volatile Organic Compounds Change the Composition and Function of the Endophytic Fungal Community in the Flowers ofInternational journal of molecular sciences · 2024Article
- Cytochrome P450 VvCYP76F14 dominates the production of wine bouquet precursors in wine grapes.Frontiers in plant science · 2024Article
- Plant Engineering to Enable Platforms for Sustainable Bioproduction of Terpenoids.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Uncovering the transcriptional responses of tobacco (Nicotiana tabacum L.) roots to Ralstonia solanacearum infection: a comparative study of resistant and susceptible cultivars.BMC plant biology · 2023Article
- Terpene produced by coexpression of the TPS and P450 genes from Lavandula angustifolia protects plants from herbivore attacks during budding stages.BMC plant biology · 2023Article
- Promoter characterization of a citrus linalool synthase gene mediating interspecific variation in resistance to a bacterial pathogen.BMC plant biology · 2023Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acyclic monoterpene alcohol linalool is one of the most frequently encountered volatile compounds in floral scents. Various linalool oxides are usually emitted along with linalool, some of which are cyclic, such as the furanoid lilac compounds. Recent work has revealed the coexistence of two flower-expressed linalool synthases that produce the (S)- or (R)-linalool enantiomers and the involvement of two P450 enzymes in the linalool oxidation in the flowers of Arabidopsis thaliana. Partially redundant enzymes may also contribute to floral linalool metabolism. Here, we provide evidence that CYP76C1 is a multifunctional enzyme that catalyzes a cascade of oxidation reactions and is the major linalool metabolizing oxygenase in Arabidopsis flowers. Based on the activity of the recombinant enzyme and mutant analyses, we demonstrate its prominent role in the formation of most of the linalool oxides identified in vivo, both as volatiles and soluble conjugated compounds, including 8-hydroxy, 8-oxo, and 8-COOH-linalool, as well as lilac aldehydes and alcohols. Analysis of insect behavior on CYP76C1 mutants and in response to linalool and its oxygenated derivatives demonstrates that CYP76C1-dependent modulation of linalool emission and production of linalool oxides contribute to reduced floral attraction and favor protection against visitors and pests.
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