Evidence map›Paper›PMID 26475745›Full record

ArticleThe international journal of neuropsychopharmacology2016

Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants.

Andrew Stuart Gibbons, Won Je Jeon, Elizabeth Scarr, Brian Dean

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. Functional coupling of MEuropean archives of psychiatry and clinical neuroscience · 2020
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew Stuart GibbonsMolecular Psychiatry Laboratories, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean); Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean).
Won Je JeonMolecular Psychiatry Laboratories, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean); Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean).
Elizabeth ScarrMolecular Psychiatry Laboratories, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean); Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean).
Brian DeanMolecular Psychiatry Laboratories, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean); Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean).
Florey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasingly, data are implicating muscarinic receptors in the aetiology and treatment of mood disorders. This led us to measure levels of different muscarinic receptor-related parameters in the cortex from people with mood disorders and the CNS of rats treated with mood stabilisers and antidepressant drugs.

methodsWe measured [(3)H]AF-DX 384 binding in BA 46 and BA 24 from subjects with bipolar disorders (n = 14), major depressive disorders (n = 19), as well as age- and sex-matched controls (n = 19) and the CNS of rats treated with fluoxetine or imipramine. In addition, we used Western blots to measure levels of CHRM2 protein and oxotremorine-M stimulated [(35)S]GTPγS binding as a measure of CHRM 2 / 4 signaling.

resultsCompared with controls, [(3)H]AF-DX 384 binding was lower in BA 24 and BA 46 in bipolar disorders and major depressive disorders, while CHRM2 protein and oxotremorine-M stimulated [(35)S]GTPγS binding was only lower in BA 24. Compared with vehicle, treatment with mood stabilisers, antidepressant drugs for 10 days, or imipramine for 28 days resulted in higher levels of in [(3)H]AF-DX 384 binding select regions of rat CNS.

conclusionsOur data suggest that levels of CHRM2 are lower in BA 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region. Our data also suggest increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants.

Indexed as

AnimalsAntidepressive AgentsAntimanic AgentsBipolar DisorderCerebral CortexDisease Models, AnimalFemaleFluoxetineHumansImipramineMajor Depressive DisorderMaleMiddle AgedMuscarinic AgonistsOxotremorinePirenzepineAFDX 384Antidepressive AgentsAntimanic AgentsFluoxetineImipramineMuscarinic AgonistsOxotremorineoxotremorine MPirenzepineRadiopharmaceuticalsReceptor, Muscarinic M2Tritiumbipolar disordersCortexlithiummajor depressive disordersmuscarinic receptors

Identifiers

PMID26475745
PMCPMC4851264
OpenAlexW2281571957

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.