ArticleThe neuroradiology journal2015
Predicting degree of myelination based on diffusion tensor imagining of canines with mucopolysaccharidosis type I.
Article in The neuroradiology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology.NeuroImage · 2021Pooled it
- Diffusion tensor imaging with free-water correction reveals distinctions between severe and attenuated subtypes in Mucopolysaccharidosis type I.Journal of inherited metabolic disease · 2025Article
- Associations between N-Acetylaspartate and white matter integrity in individuals with schizophrenia and unaffected relatives.Psychiatry research. Neuroimaging · 2023Article
- Clinical and pathological characterization of ophthalmic disease in a canine model of mucopolysaccharidosis type I.Journal of inherited metabolic disease · 2023Article
- Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study.Brain structure & function · 2021Article
- Myelination of Callosal Axons Is Hampered by Early and Late Forelimb Amputation in Rats.Cerebral cortex communications · 2021Article
- Companion animal models of neurological disease.Journal of neuroscience methods · 2020Review
- Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans.NeuroImage. Clinical · 2020Article
- Quantitative DTI metrics in a canine model of Krabbe disease: comparisons versus age-matched controls across multiple ages.The neuroradiology journal · 2018Article
- Diffusion tensor imaging findings suggestive of white matter alterations in a canine model of mucopolysaccharidosis type I.The neuroradiology journal · 2018Article
- Quantitative diffusion tensor imaging analysis does not distinguish pediatric canines with mucopolysaccharidosis I from control canines.The neuroradiology journal · 2017Article
- Novel region of interest interrogation technique for diffusion tensor imaging analysis in the canine brain.The neuroradiology journal · 2017Article
- Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.The neuroradiology journal · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThis study examined the effect of mucopolysaccharidosis (MPS) type 1 on diffusion tensor imaging (DTI) metrics in the canine brain. We hypothesized 1) white matter regions in the MPS brain would show decreased fractional anisotropy (FA) and increased radial diffusivity (RD) compared to the same regions in normal brain, 2) compared to FA, RD would more closely correlate with myelin density and fiber coherence, and 3) DTI and histological data from the normal brain could be used to accurately predict degree of myelination in the MPS brain using DTI metrics.
methodsWe performed DTI imaging on one normal canine brain and two MPS brains on a 7T MR scanner and generated FA and RD maps. Brains were sectioned and stained with a gold chloride stain for myelin to obtain myelin optical density and fiber coherence values. The three brains were compared using the DTI and histology metrics.
resultsMost measured regions in one MPS brain and all measured regions in the other MPS brain exhibited decreased FA, increased RD, and decreased myelin density in white matter. FA and RD significantly correlated with myelin density in the normal brain but failed to reach significance in either MPS brain. A predictive model using FA but not RD was able to accurately predict degree of myelination in one MPS brain.
conclusionDysmyelination in the MPS brain results in decreased FA and increased RD. However, in the small sample, FA and RD were values not significantly correlated with myelination in either MPS brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.