ArticleBMC developmental biology2015
Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells.
Article in BMC developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Sox17 and Other SoxF-Family Proteins Play Key Roles in the Hematopoiesis of Mouse Embryos.Cells · 2024Review
- A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.Development (Cambridge, England) · 2022Article
- Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells.Stem cell reviews and reports · 2021Article
- Modeling early stages of endoderm development in epiblast stem cell aggregates with supply of extracellular matrices.Development, growth & differentiation · 2020Article
- Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.Development (Cambridge, England) · 2018Article
- Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk.Biology of reproduction · 2018Article
- Identification, molecular characterization and analysis of the expression pattern of SoxF subgroup genes the Yellow River carp, Cyprinus carpio.Journal of genetics · 2018Article
- The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells.BMC evolutionary biology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in primitive endoderm in the late blastocyst, although its function in this cell lineage remains unclear.
resultsHere we characterize the function of Sox7 in primitive endoderm differentiation using mouse embryonic stem (ES) cells as a model system. We show that ectopic expression of Sox7 in ES cells has a marginal effect on triggering differentiation into primitive endoderm-like cells. We also show that targeted disruption of Sox7 in ES cells does not affect differentiation into primitive endoderm cells in embryoid body formation as well as by forced expression of Gata6.
conclusionsThese data indicate that Sox7 function is supplementary and not essential for this differentiation from ES cells.
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