ReviewCurrent topics in behavioral neurosciences2016
Motivational Processes Underlying Substance Abuse Disorder.
Review in Current topics in behavioral neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- The rise and fall of substance use during treatment: Applying recency and expectancy principles to daily substance use patterns.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Trial
- The recreational-to-habitual shift in psychostimulant use is an economic demand parameter that is unrelated to drug consumption levels (under normal and punishment conditions).bioRxiv : the preprint server for biology · 2026Article
- Effect of gonadectomy and hormone replacement on habenula-induced dopamine inhibition in female and male rats.Journal of neuroendocrinology · 2026Article
- Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Found in translation: orexin receptor antagonism for the treatment of opioid use disorder.Translational psychiatry · 2025Review
- Dopamine receptor sensitivity and Pavlovian conditioned approach.Research square · 2025Article
- Transcending Self Therapy Virtual Reality Expansion: Effect on Engagement, Completion and Temporal Usage Patterns.Journal of medical extended reality · 2025Article
- Synthetic exendin-4 disrupts responding to reward predictive incentive cues in male rats.Frontiers in behavioral neuroscience · 2024Article
- Review
- Gene expression genetics of the striatum of Diversity Outbred mice.Scientific data · 2023Article
- Gene expression genetics of the striatum of Diversity Outbred mice.bioRxiv : the preprint server for biology · 2023Article
- Genetic overlap between mood instability and alcohol-related phenotypes suggests shared biological underpinnings.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Contrasting dose-dependent effects of acute intravenous methamphetamine on lateral hypothalamic extracellular glucose dynamics in male and female rats.Journal of neurophysiology · 2022Article
- At-risk alcohol users have disrupted valence discrimination during reward anticipation.Addiction biology · 2022Article
- Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction.The European journal of neuroscience · 2022Review
- The influence of reinforcement schedule on experience-dependent changes in motivation.Journal of the experimental analysis of behavior · 2022Article
- New directions in modelling dysregulated reward seeking for food and drugs.Neuroscience and biobehavioral reviews · 2022Review
- Suboxone: History, controversy, and open questions.Frontiers in psychiatry · 2022Review
- Understanding the Progression from Early Alcohol Use Experimentation to Alcohol Use Disorder: Testing Vulnerability by Experience Interactions Using a Two-Part Latent Growth Curve Model.Research on child and adolescent psychopathology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Drug addiction is a syndrome of dysregulated motivation, evidenced by intense drug craving and compulsive drug-seeking behavior. In the search for 'common neurobiological substrates of addiction to different classes of drugs, behavioral neuroscientists have attempted to determine the neural basis for a number of motivational concepts and describe how they are changed by repeated drug use. Here, we describe these concepts and summarize previous work describing three major neural systems that play distinct roles in different conceptual aspects of motivation: (1) a nigrostriatal system that is involved in two forms of instrumental learning, (2) a ventral striatal system that is involved in Pavlovian incentive motivation and negative reinforcement, and (3) frontal cortical areas that regulate decision making and motivational processes. Within striatal systems, drug addiction can involve a transition from goal-oriented, incentive processes to automatic, habit-based responding. In the cortex, weak inhibitory control is a predisposing factor to, as well as a consequence of, repeated drug intake. However, these transitions are not absolute, and addiction can occur without a transition to habit-based responding, occurring as a result of the overvaluation of drug outcomes and hypersensitivity to incentive properties of drug-associated cues. Finally, we point out that addiction is not monolithic and can depend not only on individual differences between addicts, but also on the neurochernical action of specific drug classes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.