ArticleMarine biotechnology (New York, N.Y.)2016
Mapping QTL for Resistance Against Viral Nervous Necrosis Disease in Asian Seabass.
Article in Marine biotechnology (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Predominantly Independent Genetic Control Between Growth and Visceral White Nodules Disease Resistance Revealed by High-Density Linkage Map and QTL Mapping inInternational journal of molecular sciences · 2026Article
- Transcriptome Analysis and Hub Gene Identification in the Brain Cell Lines of the Spotted Knifejaw (International journal of molecular sciences · 2026Article
- Article
- QTL Mapping-Based Identification of Visceral White-Nodules Disease Resistance Genes inInternational journal of molecular sciences · 2024Article
- Review
- Effects of rrm1 on NNV Resistance Revealed by RNA-seq and Gene Editing.Marine biotechnology (New York, N.Y.) · 2021Article
- Toward Genome-Based Selection in Asian Seabass: What Can We Learn From Other Food Fishes and Farm Animals?Frontiers in genetics · 2021Review
- Combining Multiple Approaches and Models to Dissect the Genetic Architecture of Resistance to Infections in Fish.Frontiers in genetics · 2020Review
- Mapping and Validating QTL for Fatty Acid Compositions and Growth Traits in Asian Seabass.Marine biotechnology (New York, N.Y.) · 2019Article
- Predicting Growth Traits with Genomic Selection Methods in Zhikong Scallop (Chlamys farreri).Marine biotechnology (New York, N.Y.) · 2018Article
- GWAS analysis using interspecific backcross progenies reveals superior blue catfish alleles responsible for strong resistance against enteric septicemia of catfish.Molecular genetics and genomics : MGG · 2018Article
- The FTO Gene Is Associated with Growth and Omega-3/-6 Ratio in Asian Seabass.Marine biotechnology (New York, N.Y.) · 2018Article
- Mapping QTL for Omega-3 Content in Hybrid Saline Tilapia.Marine biotechnology (New York, N.Y.) · 2018Article
- A Genome-Wide Association Study Reveals That Genes with Functions for Bone Development Are Associated with Body Conformation in Catfish.Marine biotechnology (New York, N.Y.) · 2017Article
- QTL Mapping for Resistance to Iridovirus in Asian Seabass Using Genotyping-by-Sequencing.Marine biotechnology (New York, N.Y.) · 2017Article
- Construction of the First High-Density Genetic Linkage Map and Analysis of Quantitative Trait Loci for Growth-Related Traits in Sinonovacula constricta.Marine biotechnology (New York, N.Y.) · 2017Article
- Regional genetic diversity for NNV grouper viruses across the Indo-Asian region - implications for selecting virus resistance in farmed groupers.Scientific reports · 2017Article
- Genome-Wide Association Study Identifies Loci Associated with Resistance to Viral Nervous Necrosis Disease in Asian Seabass.Marine biotechnology (New York, N.Y.) · 2017Article
- Aquaculture genomics, genetics and breeding in the United States: current status, challenges, and priorities for future research.BMC genomics · 2017Review
- GWAS analysis of QTL for enteric septicemia of catfish and their involved genes suggest evolutionary conservation of a molecular mechanism of disease resistance.Molecular genetics and genomics : MGG · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral nervous necrosis disease (VNN), caused by nervous necrosis virus (NNV), leads to mass mortality in mariculture. However, phenotypic selection for resistance against VNN is very difficult. To facilitate marker-assisted selection (MAS) for resistance against VNN and understanding of the genetic architecture underlying the resistance against this disease, we mapped quantitative trait loci (QTL) for resistance against VNN in Asian seabass. We challenged fingerlings at 37 days post-hatching (dph), from a single back-cross family, with NNV at a concentration of 9 × 10(6) TCID50/ml for 2 h. Daily mortalities were recorded and collected. A panel of 330 mortalities and 190 surviving fingerlings was genotyped using 149 microsatellites with 145 successfully mapped markers covering 24 linkage groups (LGs). Analysis of QTL for both resistance against VNN and survival time was conducted using interval mapping. Five significant QTL located in four LGs and eight suggestive QTL in seven LGs were identified for resistance. Another five significant QTL in three LGs and five suggestive QTL in three LGs were detected for survival time. One significant QTL, spanning 3 cM in LG20, was identified for both resistance and survival time. These QTL explained 2.2-4.1% of the phenotypic variance for resistance and 2.2-3.3% of the phenotypic variance for survival time, respectively. Our results suggest that VNN resistance in Asian seabass is controlled by many loci with small effects. Our data provide information for fine mapping of QTL and identification of candidate genes for a better understanding of the mechanism of disease resistance.
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