Evidence map›Paper›PMID 26475140›Full record

ArticleEJNMMI research2015

Imaging cerebral tryptophan metabolism in brain tumor-associated depression.

Edit Bosnyák, David O Kamson, Michael E Behen, Geoffrey R Barger, Sandeep Mittal, Csaba Juhász

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02367469 (Tryptophan Metabolism in Human Brain Tumors), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02367469 completednot on this map

Tryptophan Metabolism in Human Brain Tumors

TypeobservationalSponsorWayne State UniversityRan2014 to 2021Enrolled105ConditionsBrain Tumors
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Edit BosnyákDepartment of Pediatrics, Wayne State University, 3901 Beaubien Street, Detroit, MI, 48201, USA. drbosnyakedit@gmail.com.
David O KamsonDepartment of Pediatrics, Wayne State University, 3901 Beaubien Street, Detroit, MI, 48201, USA. promeoso@hotmail.com.
Michael E BehenDepartment of Pediatrics, Wayne State University, 3901 Beaubien Street, Detroit, MI, 48201, USA. mbehen@pet.wayne.edu.
Geoffrey R BargerDepartment of Neurology, Wayne State University, 4201 St. Antoine, Detroit, MI, 48201, USA. gbarger@med.wayne.edu.
Sandeep MittalDepartment of Neurosurgery, Wayne State University, 4160 John R., Suite 930, Detroit, MI, 48201, USA. smittal@med.wayne.edu.
Csaba JuhászDepartment of Pediatrics, Wayne State University, 3901 Beaubien Street, Detroit, MI, 48201, USA. juhasz@pet.wayne.edu.
Wayne State University · US

Funding

Tryptophan Metabolism in Human Brain TumorsR01CA123451 · NCI · WAYNE STATE UNIVERSITY · PI JUHASZ, CSABA, MITTAL, SANDEEP · 2008 to 2018
$3.1M
NCI NIH HHS R01 CA123451
6 · The paper itself

Abstract

backgroundDepression in patients with brain tumors is associated with impaired quality of life and shorter survival. Altered metabolism of tryptophan to serotonin and kynurenine metabolites may play a role in tumor-associated depression. Our recent studies with alpha[(11)C]methyl-L-tryptophan (AMT)-PET in brain tumor patients indicated abnormal tryptophan metabolism not only in the tumor mass but also in normal-appearing contralateral brain. In the present study, we explored if tryptophan metabolism in such brain regions is associated with depression.

methodsTwenty-one patients (mean age: 57 years) with a brain tumor (10 meningiomas, 8 gliomas, and 3 brain metastases) underwent AMT-PET scanning. MRI and AMT-PET images were co-registered, and AMT kinetic parameters, including volume of distribution (VD', an estimate of net tryptophan transport) and K (unidirectional uptake, related to tryptophan metabolism), were measured in the tumor mass and in unaffected cortical and subcortical regions contralateral to the tumor. Depression scores (based on the Beck Depression Inventory-II [BDI-II]) were correlated with tumor size, grade, type, and AMT-PET variables.

resultsThe mean BDI-II score was 12 ± 10 (range: 2-33); clinical levels of depression were identified in seven patients (33 %). High BDI-II scores were most strongly associated with high thalamic AMT K values both in the whole group (Spearman's rho = 0.63, p = 0.004) and in the subgroup of 18 primary brain tumors (r = 0.68, p = 0.004). Frontal and striatal VD' values were higher in the depressed subgroup than in non-depressed patients (p < 0.05); the group difference was even more robust when moderately/severely depressed patients were compared to patients with no/mild depression (frontal: p = 0.005; striatal: p < 0.001). Tumor size, grade, and tumor type were not related to depression scores.

conclusionsAbnormalities of tryptophan transport and metabolism in the thalamus, striatum, and frontal cortex, measured by PET, are associated with depression in patients with brain tumor. These changes may indicate an imbalance between the serotonin and kynurenine pathways and serve as a molecular imaging marker of brain tumor-associated depression.

trial registrationClinicalTrials.gov NCT02367469.

Indexed as

Brain tumorCorticalDepressionKynurenineMagnetic resonance imagingPositron emission tomographySerotoninStriatumThalamusTryptophan

Identifiers

PMID26475140
PMCPMC4608955
OpenAlexW2104484230

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.