ArticleEcotoxicology (London, England)2016
Estrogenic contamination by manure fertilizer in organic farming: a case study with the lizard Podarcis sicula.
Article in Ecotoxicology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Glyphosate Interference in Follicular Organization in the Wall LizardInternational journal of molecular sciences · 2023Article
- Molecular and Histological Effects of Glyphosate on Testicular Tissue of the LizardInternational journal of molecular sciences · 2022Article
- Review
- Alkyphenol Exposure Alters Steroidogenesis in Male LizardAnimals : an open access journal from MDPI · 2021Article
- OctylPhenol (OP) Alone and in Combination with NonylPhenol (NP) Alters the Structure and the Function of Thyroid Gland of the Lizard Podarcis siculus.Archives of environmental contamination and toxicology · 2021Article
- Lizards as model organisms to evaluate environmental contamination and biomonitoring.Environmental monitoring and assessment · 2020Review
- How Glyphosate Impairs Liver Condition in the Field LizardBioMed research international · 2019Article
- Biodegradation of 17β-estradiol by Bacterial Co-culture Isolated from Manure.Scientific reports · 2018Article
- Metallothionein expression and synthesis in the testis of the lizard Podarcis sicula under natural conditions and following estrogenic exposure.European journal of histochemistry : EJH · 2017Article
- Exploring the Role of Estrogens in Lizard Spermatogenesis through the Study of Clomiphene and FSH Effects.International journal of endocrinology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last years, worldwide organic farming has grown exponentially; as a consequence, the use of animal manure as a soil fertility source has become the principal agricultural choice. However, the use of manure as fertilizer can increase the amount of steroid hormone metabolites in the soil. In southern Italy, lacertidae lizards are the most abundant vertebrate group in agroecosystems and have been identified as potential model species for ecotoxicological studies. The aim of this study was to understand if the manure applied in organic farming has estrogen-like effects in the lizard Podarcis sicula. Adult male lizards were captured in two organic agricultural fields (manure-treated sites) and in an uncultivated field (control site). Lizards from the two organic farms displayed hepatic biosynthetic alterations typical of an estrogenic contamination; hepatocytes contained both vitellogenin and estrogen receptor alpha transcripts and proteins, detected by in situ hybridization and immunocytochemistry. The same cells did not show cadmium, lead and metallothionein accumulation, indicative of the lack of inorganic contamination. These findings suggest that exogenous estrogens, arising from the use of manure, could affect the welfare of wild animals and animal breeding, leading to bioaccumulation of estrogens in food chain, with possible risk for human consumers. For this reason, organic farming should implement the use of sustainable practices such as crop rotation to preserve the soil biological activity, rather than organic manure as fertilizer.
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