ArticlePloS one2015
Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- No reliable gray matter alterations in idiopathic dystonia.Frontiers in neurology · 2025Pooled it
- Contributions of lifestyle, education, and cardiovascular risk factors to the brain age gap.Aging brain · 2025Article
- Resilience of Neural Cellularity to the Influence of Low Educational Level.Brain sciences · 2023Article
- Article
- Signatures of life course socioeconomic conditions in brain anatomy.Human brain mapping · 2022Article
- Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.Neuroradiology · 2022Article
- The Role of Race in Relations of Social Support to Hippocampal Volumes Among Older Adults.Research on aging · 2022Article
- Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms.Brain imaging and behavior · 2021Article
- Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities.Frontiers in neurology · 2021Review
- Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer's Disease.Journal of personalized medicine · 2020Article
- Association between Exposure to Air Pollution and Total Gray Matter and Total White Matter Volumes in Adults: A Cross-Sectional Study.Brain sciences · 2020Article
- Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020Article
- Differences in Total Brain Volume between Sexes in a Cognitively Unimpaired Elderly Population.Clinics (Sao Paulo, Brazil) · 2020Article
- The Role of Cognitive Reserve in Alzheimer's Disease and Aging: A Multi-Modal Imaging Review.Journal of Alzheimer's disease : JAD · 2018Review
- Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease.Frontiers in aging neuroscience · 2018Article
- A specific pattern of gray matter atrophy in Alzheimer's disease with depression.Journal of neurology · 2017Article
- Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.Brain : a journal of neurology · 2017Article
- Dependency criterion based brain pathological age estimation of Alzheimer's disease patients with MR scans.Biomedical engineering online · 2017Article
- A cross-sectional study to evaluate metabolic and demographic factors affecting cognitive function among low educated internal medicine outpatients.Neurosciences (Riyadh, Saudi Arabia) · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxelwise patterns of linear correlation were compared between high and low education groups, there was one cluster of greater rGM loss with aging in low versus high education elders in the left anterior cingulate cortex (p<0.05, FWE-corrected), as well as a trend in the left dorsomedial prefrontal cortex (p<0.10). These results provide preliminary indication that education might exert subtle protective effects against age-related brain changes in healthy subjects. The anterior cingulate cortex, critical to inhibitory control processes, may be particularly sensitive to such effects, possibly given its involvement in cognitive stimulating activities at school or later throughout life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.