ArticleThe European journal of neuroscience2015
Perirhinal cortex lesions impair tests of object recognition memory but spare novelty detection.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- The impact of pitolisant, an HScientific reports · 2022Article
- Reconciling the object and spatial processing views of the perirhinal cortex through task-relevant unitization.Hippocampus · 2021Review
- Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction.Journal of Alzheimer's disease : JAD · 2021Article
- Schisandra Extract and Ascorbic Acid Synergistically Enhance Cognition in Mice Through Modulation of Mitochondrial Respiration.Nutrients · 2020Article
- Significance of IL-6 Deficiency in Recognition Memory in Young Adult and Aged Mice.Behavior genetics · 2019Article
- Differentiable Processing of Objects, Associations, and Scenes within the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- 5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex.eLife · 2018Article
- Functional organization of the medial temporal lobe memory system following neonatal hippocampal lesion in rhesus monkeys.Brain structure & function · 2017Article
- Chronic cerebral hypoperfusion induced by bilateral carotid artery stenosis causes selective recognition impairment in adult mice.Neurological research · 2017Article
- Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment.The Journal of pharmacology and experimental therapeutics · 2017Review
- Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques.Alcohol (Fayetteville, N.Y.) · 2017Article
- RETRACTED: BNDF heterozygosity is associated with memory deficits and alterations in cortical and hippocampal EEG power.Behavioural brain research · 2017Article
- Familiarity-based stimulus generalization of conditioned suppression.Journal of experimental psychology. Animal learning and cognition · 2017Article
- Detecting and discriminating novel objects: The impact of perirhinal cortex disconnection on hippocampal activity patterns.Hippocampus · 2016Article
- Perirhinal cortex lesions that impair object recognition memory spare landmark discriminations.Behavioural brain research · 2016Article
- Distributed interactive brain circuits for object-in-place memory: A place for time?Brain and neuroscience advancesReview
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4 authors.
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Abstract
The present study examined why perirhinal cortex lesions in rats impair the spontaneous ability to select novel objects in preference to familiar objects, when both classes of object are presented simultaneously. The study began by repeating this standard finding, using a test of delayed object recognition memory. As expected, the perirhinal cortex lesions reduced the difference in exploration times for novel vs. familiar stimuli. In contrast, the same rats with perirhinal cortex lesions appeared to perform normally when the preferential exploration of novel vs. familiar objects was tested sequentially, i.e. when each trial consisted of only novel or only familiar objects. In addition, there was no indication that the perirhinal cortex lesions reduced total levels of object exploration for novel objects, as would be predicted if the lesions caused novel stimuli to appear familiar. Together, the results show that, in the absence of perirhinal cortex tissue, rats still receive signals of object novelty, although they may fail to link that information to the appropriate object. Consequently, these rats are impaired in discriminating the source of object novelty signals, leading to deficits on simultaneous choice tests of recognition.
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