Evidence map›Paper›PMID 26474113›Full record

ArticleCritical care medicine2016

Characteristics and Outcome of Patients With AIDS in Dutch ICUs Between 1997 and 2014.

Michaëla A Huson, Ferishta Bakhshi-Raiez, Martin P Grobusch, Evert de Jonge, Nicolette F de Keizer, Tom van der Poll

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Article in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

People living with HIV, HCV and HIV/HCV coinfection in intensive care in a German tertiary referral center 2014-2019.Infection · 2023
Article
Mortality in patients with acquired human immunodeficiency virus infection hospitalized in an intensive care unit during the period 2017-2019.Scientific reports · 2022
Article
Predictors of in-hospital mortality in a cohort of people living with HIV (PLHIV) admitted to an academic medical intensive care unit from 2009 to 2014: A retrospective cohort study.Medicine · 2022
Article
HIV treatment non-adherence is associated with ICU mortality in HIV-positive critically ill patients.Journal of the Intensive Care Society · 2021
Article
Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study.Critical care (London, England) · 2016
Observational
Improved Outcomes in Critically Ill Patients With AIDS: How Does This Trend Continue?Critical care medicine · 2016
Article

4 · The record

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Improved Outcomes in Critically Ill Patients With AIDS: How Does This Trend Continue?2016

5 · Who and what money

Authors and funding

6 authors.

Michaëla A Huson1Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands. 2Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3Stichting Nationale Intensive Care Evaluatie, Amsterdam Medical Center, Amsterdam, The Netherlands. 4Division of Internal Medicine, Department of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands. 5Department of Intensive Care, Leiden University Medical Center, Leiden, The Netherlands.

Ferishta Bakhshi-Raiez

Martin P Grobusch

Evert de Jonge

Nicolette F de Keizer

Tom van der Poll

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveKnowledge on characteristics and outcome of ICU patients with AIDS is highly limited. We aimed to determine the main reasons for admission and outcome in ICU patients with AIDS and trends over time therein.

designA retrospective study within the Dutch National Intensive Care Evaluation registry.

settingDutch ICUs. PATIENTS: We used data collected between 1997 and 2014. Characteristics of patients with AIDS were compared with ICU patients without AIDS, matched for age, sex, admission type, and admission year. Joinpoint regression analysis was applied to study trends over time.

interventionsNone. MEASUREMENTS AND MAIN

resultsWe included 1,127 patients with AIDS and 4,479 matched controls. The main admission diagnoses of patients with AIDS were respiratory infection (28.6%) and sepsis (16.9%), which were less common in controls (7.7% and 7.5%, respectively; both p < 0.0001). Patients with AIDS had increased severity of illness and in-hospital mortality (28.2% vs 17.8%; p < 0.0001) compared with controls, which was associated with a higher rate of infections at admission in patients with AIDS (58.4% vs 25.5%). Over time, the proportion of patients with AIDS admitted with an infection decreased (75% in 1999 to 56% in 2013). Mortality declined in patients with AIDS (39% in 1999 to 16% in 2013), both in patients with or without an infection. Mortality also declined in matched controls without AIDS, but to a lesser extent.

conclusionInfections are still the main reason for ICU admission in patients with AIDS, but their prevalence is declining. Outcome of patients with AIDS continued to improve during a time of widespread availability of combination antiretroviral therapy, and mortality is reaching levels similar to ICU patients without AIDS.

Indexed as

Acquired Immunodeficiency SyndromeAdultAgedAge FactorsAIDS-Related Opportunistic InfectionsAPACHECase-Control StudiesFemaleHospital MortalityHumansIntensive Care UnitsMaleMiddle AgedNetherlandsRetrospective StudiesSeverity of Illness Index

Identifiers

PMID26474113

DOI10.1097/CCM.0000000000001385

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