ArticlePloS one2015
Purification and Characterization of Bacteriocin Produced by Weissella confusa A3 of Dairy Origin.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 109 citations in OpenAlex.
- Comparative antimicrobial activity of crude and partially purified Weissella cibaria NM1 postbiotics against Klebsiella pneumoniae ATCC13382.Antonie van Leeuwenhoek · 2026Article
- Article
- Bacterial community dynamics in spontaneously fermented Ghanaian cereals, legumes, root, tuber and plantain flours.BMC microbiology · 2025Article
- Toward safer and sustainable food preservation: a comprehensive review of bacteriocins in the food industry.Bioscience reports · 2025Review
- Unveiling the Perspective onMicroorganisms · 2025Article
- Antibacterial and antibiofilm activities of bacteriocin produced by a new strain of Enterococcus faecalis BDR22.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- A Comprehensive Review on Preparation of Silver Nanoparticles from a Bacteriocin for the Natural Preservation of Food Products.Applied biochemistry and biotechnology · 2025Review
- BrSPR-20-P1 peptide isolated fromRSC advances · 2024Article
- Systematic Evaluation of Biotic and Abiotic Factors in Antifungal Microorganism Screening.Microorganisms · 2024Article
- Characterization of the broad-spectrum antibacterial activity of bacteriocin-like inhibitory substance-producing probiotics isolated from fermented foods.BMC microbiology · 2024Article
- Enhanced production of bacteriocin by3 Biotech · 2024Article
- Identification and characterization of antibacterial peptides produced byBioImpacts : BI · 2024Article
- Biosynthesis, classification, properties, and applications ofFrontiers in microbiology · 2024Review
- Article
- Under conditions closely mimicking vaginal fluid,Microbiology (Reading, England) · 2023Article
- TheFrontiers in microbiology · 2023Review
- The Weissella Genus: Clinically Treatable Bacteria with Antimicrobial/Probiotic Effects on Inflammation and Cancer.Microorganisms · 2022Review
- Purification and Characterization of Novel Anti-MRSA Peptides Produced byMolecules (Basel, Switzerland) · 2022Article
- Isolation and Characterization of Antimicrobial Peptides Isolated from Fagonia bruguieri.Applied biochemistry and biotechnology · 2022Article
- Applications of Lactic Acid Bacteria and Their Bacteriocins against Food Spoilage Microorganisms and Foodborne Pathogens.Molecules (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A dramatic increase in bacterial resistance towards currently available antibiotics has raised worldwide concerns for public health. Therefore, antimicrobial peptides (AMPs) have emerged as a promisingly new group of therapeutic agents for managing infectious diseases. The present investigation focusses on the isolation and purification of a novel bacteriocin from an indigenous sample of cow milk and it's mode of action. The bacteriocin was isolated from Weissella confusa A3 that was isolated from the sample and was shown to have inhibitory activity towards pathogenic bacteria namely Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa and Micrococcus luteus. The bacteriocin was shown to be heat stable and functioned well at low pH (2 to 6). Reduction of activity was shown after treatment with proteinase K, trypsin and peptidase that confirmed the proteinaceous nature of the compound. MALDI-TOF analysis of the sample gave a mass approximating 2.7 kDa. The membrane of the bacteria was disrupted by the bacteriocin causing SYTOX® green dye to enter the cell and bind to the bacterial DNA giving fluorescence signal. Bacterial cell treated with the bacteriocin also showed significant morphological changes under transmission electron microscope. No virulence and disease related genes can be detected from the genome of the strain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.