ArticleeLife2015
Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Astroglia's role in synchronized spontaneous neuronal activity: from physiology to pathology.Frontiers in cellular neuroscience · 2025Review
- Gene Expression at the Tripartite Synapse: Bridging the Gap Between Neurons and Astrocytes.Advances in neurobiology · 2024Review
- Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist.International journal of molecular sciences · 2023Article
- Elevated insulin growth factor-1 in dentate gyrus induces cognitive deficits in pre-term newborns.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Diverse role of NMDA receptors for dendritic integration of neural dynamics.PLoS computational biology · 2023Article
- The Pathological Effects of Circulating Hydrophobic Bile Acids in Alzheimer's Disease.Journal of Alzheimer's disease reports · 2023Review
- The atypical Rho GTPase Rnd2 is critical for dentate granule neuron development and anxiety-like behavior during adult but not neonatal neurogenesis.Molecular psychiatry · 2021Article
- Kainate receptors regulate the functional properties of young adult-born dentate granule cells.Cell reports · 2021Article
- CaBiophysical journal · 2020Article
- Stroke Primes New Hippocampal Neurons for Hyperexcitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Development of Depotentiation in Adult-Born Dentate Granule Cells.Frontiers in cell and developmental biology · 2019Article
- Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons.Neuroscience letters · 2018Article
- Article
- Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons.Neuron · 2017Article
- Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons.Scientific reports · 2017Article
- Article
- Neuronal survival in the brain: neuron type-specific mechanisms.Cell death & disease · 2017Review
- Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NMDA receptor (NMDAR)-dependent forms of synaptic plasticity are thought to underlie the assembly of developing neuronal circuits and to play a crucial role in learning and memory. It remains unclear how NMDAR might contribute to the wiring of adult-born granule cells (GCs). Here we demonstrate that nascent GCs lacking NMDARs but rescued from apoptosis by overexpressing the pro-survival protein Bcl2 were deficient in spine formation. Insufficient spinogenesis might be a general cause of cell death restricted within the NMDAR-dependent critical time window for GC survival. NMDAR loss also led to enhanced mushroom spine formation and synaptic AMPAR activity throughout the development of newborn GCs. Moreover, similar elevated synapse maturation in the absence of NMDARs was observed in neonate-generated GCs and CA1 pyramidal neurons. Together, these data suggest that NMDAR operates as a molecular monitor for controlling the activity-dependent establishment and maturation rate of synaptic connections between newborn neurons and others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.