ArticleMarine drugs2015
Cyanobacterial Toxic and Bioactive Peptides in Freshwater Bodies of Greece: Concentrations, Occurrence Patterns, and Implications for Human Health.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines.Environmental toxicology · 2026Article
- Impact of climate change on formation of nitrogenous disinfection by-products. Part II: water blooming and enrichment by humic substances.Environmental science and pollution research international · 2026Article
- Biotransformation Dynamics and Products of Cyanobacterial Secondary Metabolites in Surface Waters.Environmental science & technology · 2025Article
- A Highly Convergent Synthesis Route for Adda: A Non-Proteinogenic Amino Acid Unit in Cyanobacteria.The Journal of organic chemistry · 2025Article
- Taxonomic and functional metagenomic assessment of a Dolichospermum bloom in a large and deep lake south of the Alps.FEMS microbiology ecology · 2024Article
- Cyanobacteria and Their Metabolites in Mono- and Polidominant Shallow Eutrophic Temperate Lakes.International journal of environmental research and public health · 2022Article
- Microcystins in Water: Detection, Microbial Degradation Strategies, and Mechanisms.International journal of environmental research and public health · 2022Review
- Article
- Anabaenopeptins: What We Know So Far.Toxins · 2021Review
- Article
- Insight into Unprecedented Diversity of Cyanopeptides in Eutrophic Ponds Using an MS/MS Networking Approach.Toxins · 2020Article
- Article
- Diversity, Cyanotoxin Production, and Bioactivities of Cyanobacteria Isolated from Freshwaters of Greece.Toxins · 2019Article
- Occurrence and diversity of cyanotoxins in Greek lakes.Scientific reports · 2018Article
- Monitoring and research of microcystins and environmental factors in a typical artificial freshwater aquaculture pond.Environmental science and pollution research international · 2018Article
- Article
- Evolution of Anabaenopeptin Peptide Structural Variability in the CyanobacteriumFrontiers in microbiology · 2017Article
- Cyanobacteria of Greece: an annotated checklist.Biodiversity data journal · 2016Article
- Distribution and Habitat Specificity of Potentially-Toxic Microcystis across Climate, Land, and Water Use Gradients.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacterial harmful algal blooms represent one of the most conspicuous waterborne microbial hazards in aquatic environments mostly due to the production of toxic secondary metabolites, mainly microcystins (MCs). Other bioactive peptides are frequently found in cyanobacterial blooms, yet their concentration and ecological relevance is still unknown. In this paper we studied the presence and concentration of cyanobacterial peptides (microcystins, anabaenopeptins, anabaenopeptilides) in 36 Greek freshwater bodies, using HPLC-DAD, ELISA, and PP1IA. Microcystins were found in more than 90% of the samples investigated, indicating that microcystin-producing strains seem to also occur in lakes without blooms. Microcystins MC-RR, MC-LR, and MC-YR were the main toxin constituents of the bloom samples. Anabaenopeptin A and B were predominant in some samples, whereas anabaenopeptolide 90A was the only peptide found in Lake Mikri Prespa. The intracellular concentrations of anabaenopeptins produced by cyanobacterial bloom populations are determined for the first time in this study; the high (>1000 µg·L(-1)) anabaenopeptin concentration found indicates there may be some impacts, at least on the ecology and the food web structure of the aquatic ecosystems. The maximum intracellular MC values measured in Lakes Kastoria and Pamvotis, exceeding 10,000 µg·L(-1), are among the highest reported.
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