SynthesisMolecules (Basel, Switzerland)2015
A Systematic Review of the Anxiolytic-Like Effects of Essential Oils in Animal Models.
Synthesis in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.Frontiers in public health · 2023Pooled it
- Aromatherapy for Symptom Relief in Patients with Burn: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis.Scientific reports · 2019Pooled it
- Integrated Chemical, In Silico, and Functional Neurobehavioral Evaluation of Three Essential Oils in Acute Anxiety- and Depression-Related Mouse Models.Molecules (Basel, Switzerland) · 2026Article
- Essential Oil ofPlants (Basel, Switzerland) · 2026Review
- Aromatic Volatile Compounds of Essential Oils: Distribution, Chemical Perspective, Biological Activity, and Clinical Applications.Food science & nutrition · 2025Review
- Effects of Essential Oils in the Treatment of Acute Rhinosinusitis: A Systematic Review.Laryngoscope investigative otolaryngology · 2025Review
- Unraveling the Neuropharmacological Properties ofPharmaceuticals (Basel, Switzerland) · 2025Review
- Review
- Dose-dependent responses: a preliminary investigation into the olfactory effects of essential oil concentrations on canine behavior.Veterinary research communications · 2024Article
- Application ofMolecules (Basel, Switzerland) · 2024Article
- Therapeutic Potential of Myrtenal and Its Derivatives-A Review.Life (Basel, Switzerland) · 2023Review
- Olfactory Stimulation as Environmental Enrichment for Domestic Horses-A Review.Animals : an open access journal from MDPI · 2023Review
- Hawaiian Plants with Beneficial Effects on Sleep, Anxiety, and Mood, etc.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Essential Oils: Chemistry and Pharmacological Activities.Biomolecules · 2023Review
- Aromatherapy in anxiety, depression, and insomnia: A bibliometric study and visualization analysis.Heliyon · 2023Article
- Enteric Methane Emissions from Dairy-Beef Steers Supplemented with the Essential Oil Blend Agolin Ruminant.Animals : an open access journal from MDPI · 2023Article
- Screening for Neuroprotective and Rapid Antidepressant-like Effects of 20 Essential Oils.Biomedicines · 2023Article
- Anxiolytic-like Effect of Inhaled Cinnamon Essential Oil and Its Main Component Cinnamaldehyde in Animal Models.Molecules (Basel, Switzerland) · 2022Article
- Exploring the Chemical Composition of Bulgarian Lavender Absolute (Plants (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical efficacy of standardized essential oils (such as Lavender officinalis), in treating anxiety disorders strongly suggests that these natural products are an important candidate source for new anxiolytic drugs. A systematic review of essential oils, their bioactive constituents, and anxiolytic-like activity is conducted. The essential oil with the best profile is Lavendula angustifolia, which has already been tested in controlled clinical trials with positive results. Citrus aurantium using different routes of administration also showed significant effects in several animal models, and was corroborated by different research groups. Other promising essential oils are Citrus sinensis and bergamot oil, which showed certain clinical anxiolytic actions; along with Achillea wilhemsii, Alpinia zerumbet, Citrus aurantium, and Spiranthera odoratissima, which, like Lavendula angustifolia, appear to exert anxiolytic-like effects without GABA/benzodiazepine activity, thus differing in their mechanisms of action from the benzodiazepines. The anxiolytic activity of 25 compounds commonly found in essential oils is also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.