ArticleMolecules (Basel, Switzerland)2015
Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
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- Putative Identification of New Phragmaline-Type Limonoids from the Leaves ofMolecules (Basel, Switzerland) · 2023Article
- The Prospects ofAntioxidants (Basel, Switzerland) · 2022Review
- Anti-Cancer and Anti-Inflammatory Activities of Three New Chromone Derivatives from the Marine-DerivedMarine drugs · 2021Article
- Rare Chromone Derivatives from the Marine-DerivedMarine drugs · 2021Article
- The recent use ofHeliyon · 2020Review
- Chemical Structures and Biological Activities of Limonoids from the GenusMolecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC50 values≤45.44 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC50 values≤36.32 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.
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