Trial reportAnnals of surgery2016
Randomized Controlled Trial of Pancreaticojejunostomy versus Stapler Closure of the Pancreatic Stump During Distal Pancreatectomy to Reduce Pancreatic Fistula.
Trial report in Annals of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01384617 (Roux-en-Y Anastomosis of the Pancreatic Stump Following Distal Pancreatectomy), which is not on this map. Cited by 56 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Roux-en-Y Anastomosis of the Pancreatic Stump Following Distal Pancreatectomy
Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Quality assurance of surgical interventions for pancreatic cancer: systematic review of multicentre randomized clinical trials.BJS open · 2025Pooled it
- Reinforced stapling does not reduce postoperative pancreatic fistula in distal pancreatectomy: a systematic review and meta-analysis.Updates in surgery · 2023Pooled it
- Pooled it
- Pooled it
- Risk factors and preventive strategies for post-operative pancreatic fistula after pancreatic surgery: a comprehensive review.Scandinavian journal of gastroenterology · 2016Pooled it
- A randomized controlled trial of stapled versus ultrasonic transection in distal pancreatectomy.Surgical endoscopy · 2022Trial
- 2-octyl cyanoacrylate sealing of the pancreatic remnant after distal pancreatectomy - A prospective pilot study.PloS one · 2018Trial
- Reinforced staplers for distal pancreatectomy.Langenbeck's archives of surgery · 2017Trial
- The Progress of Pancreatectomy for Pancreatic Cancer Treatment-Lessons Learned and Future Challenges.Cancers · 2026Review
- Thick pancreas, dense duct branching, and limited fibrosis as risk factors for pancreatic fistula after distal pancreatectomy.BMC gastroenterology · 2026Article
- A Multicenter, Single-Blind, Randomized Trial Comparing Stapler Closure With Clip-on-Staple Method Versus Stapler Closure Alone During Distal Pancreatectomy (CLIP-DP Trial).Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- Prediction of Postoperative Pancreatic Fistula Occurrence by the Pancreatic Stump Shape and Remnant Pancreatic Volume Measured Using AI-Guided Three-Dimensional Simulation.Annals of surgical oncology · 2026Article
- Application of reinforced U-shaped suture technique in laparoscopic distal pancreatectomy: an analysis of 165 consecutive cases.BMC surgery · 2026Article
- Evidence-Based Strategies for Mitigating Pancreatic Fistula After Distal Pancreatectomy: A Systematic Review of Randomized Clinical Trials.Journal of clinical medicine · 2026Review
- Review
- Laparoscopic distal pancreatectomy with pancreatic remnant-gastric coverage: a modified technique to reduce postoperative pancreatic fistula.Surgical endoscopy · 2025Article
- Efficacy of pancreaticojejunostomy of the pancreatic stump during distal or central pancreatectomy.Langenbeck's archives of surgery · 2024Article
- Article
- Retroperitonealization of the pancreatic stump in distal pancreatectomy: a novel technique to reduce postoperative pancreatic fistula.Langenbeck's archives of surgery · 2023Article
- Pancreas Ligation Device for Distal Pancreatectomy: An Ex Vivo Follow-Up Porcine Study.Cureus · 2023Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to evaluate in a multicenter randomized controlled trial (RCT) whether pancreaticojejunostomy (PJ) of pancreatic stump decreases the incidence of pancreatic fistula after distal pancreatectomy (DP) compared with stapler closure.
backgroundSeveral studies reported that PJ of pancreatic stump reduces the incidence of pancreatic fistula after DP. However, no RCT has confirmed the efficacy of PJ of pancreatic stump.
methodsOne hundred thirty-six patients scheduled for DP were enrolled in this study between June 2011 and March 2014 at 6 high-volume surgical centers in Japan. Enrolled patients were randomized to either stapler closure or PJ. The primary endpoint was the incidence of pancreatic fistula based on the International Study Group on Pancreatic Fistula criteria. This RCT was registered with ClinicalTrials.gov (NCT01384617).
resultsSixty-one patients randomized to stapler and 62 patients randomized to PJ were analyzed by intention-to-treat. Pancreatic fistula occurred in 23 patients (37.7%) in the stapler closure group and 24 (38.7%) in the PJ group (P = 0.332) in intention-to-treat analysis. The incidence of clinically relevant pancreatic fistula (grade B or C) was 16.4% for stapler closure and 9.7% for PJ (P = 0.201). Mortality was zero in both groups. In a subgroup analysis for thickness of pancreas greater than 12 mm, the incidence of clinically relevant pancreatic fistula occurred in 22.2% of the patients in the stapler closure group and in 6.2% of the PJ group (P = 0.080).
conclusionsPJ of the pancreatic stump during DP does not reduce pancreatic fistula compared with stapler closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.