ArticlePloS one2015
Multiparametric MRI of Epiphyseal Cartilage Necrosis (Osteochondrosis) with Histological Validation in a Goat Model.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Relaxation Time Mapping of Early-Stage Osteonecrosis of the Femoral Head: An In Vivo Piglet Model Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Relationship between the extent of vascular injury and the evolution of surgically induced osteochondrosis lesions in a piglet model.PloS one · 2024Article
- Naturally occurring osteochondrosis latens lesions identified by quantitative and morphological 10.5 T MRI in pigs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Longitudinal 3T MRI TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Quantitative T2 and T1ρ mapping are sensitive to ischemic injury to the epiphyseal cartilage in an in vivo piglet model of Legg-Calvé-Perthes disease.Osteoarthritis and cartilage · 2022Article
- T1ρ and T2 mapping detect acute ischemic injury in a piglet model of Legg-Calvé-Perthes disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Identification of Areas of Epiphyseal Cartilage Necrosis at Predilection Sites of Juvenile Osteochondritis Dissecans in Pediatric Cadavers.The Journal of bone and joint surgery. American volume · 2018Article
- Quantitative MRI Helps to Detect Hip Ischemia: Preclinical Model of Legg-Calvé-Perthes Disease.Radiology · 2018Article
- Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the osteoarthritis initiative.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- In vivo visualization using MRI TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans.Magnetic resonance in medicine · 2017Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate multiple MRI parameters in a surgical model of osteochondrosis (OC) in goats.
methodsFocal ischemic lesions of two different sizes were induced in the epiphyseal cartilage of the medial femoral condyles of goats at 4 days of age by surgical transection of cartilage canal blood vessels. Goats were euthanized and specimens harvested 3, 4, 5, 6, 9 and 10 weeks post-op. Ex vivo MRI scans were conducted at 9.4 Tesla for mapping the T1, T2, T1ρ, adiabatic T1ρ and TRAFF relaxation times of articular cartilage, unaffected epiphyseal cartilage, and epiphyseal cartilage within the area of the induced lesion. After MRI scans, safranin O staining was conducted to validate areas of ischemic necrosis induced in the medial femoral condyles of six goats, and to allow comparison of MRI findings with the semi-quantitative proteoglycan assessment in corresponding safranin O-stained histological sections.
resultsAll relaxation time constants differentiated normal epiphyseal cartilage from lesions of ischemic cartilage necrosis, and the histological staining results confirmed the proteoglycan (PG) loss in the areas of ischemia. In the scanned specimens, all of the measured relaxation time constants were higher in the articular than in the normal epiphyseal cartilage, consistently allowing differentiation between these two tissues.
conclusionsMultiparametric MRI provided a sensitive approach to discriminate between necrotic and viable epiphyseal cartilage and between articular and epiphyseal cartilage, which may be useful for diagnosing and monitoring OC lesions and, potentially, for assessing effectiveness of treatment interventions.
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