Evidence map›Paper›PMID 26473596›Full record

ArticlePloS one2015

Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.

Benedicte Meyer, Chinh Bkrong Thuy Nguyen, Aurora Moen, Even Fagermoen, Dag Sulheim, Hilde Nilsen, Vegard Bruun Wyller, Johannes Gjerstad

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Benedicte MeyerDept. of Paediatrics, Akershus University Hospital, Oslo, Norway.
Chinh Bkrong Thuy NguyenDept. of Paediatrics, Akershus University Hospital, Oslo, Norway.
Aurora MoenDept. of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.
Even FagermoenDept. of Anaesthesiology and Critical Care, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
Dag SulheimDept. of Paediatrics, Lillehammer County Hospital, Lillehammer, Norway; Dept. of Paediatrics, Oslo University Hospital, Oslo, Norway.
Hilde NilsenInstitute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway; Section for Clinical Molecular Biology, Akershus University Hospital, Oslo, Norway.
Vegard Bruun WyllerDept. of Paediatrics, Akershus University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway.
Johannes GjerstadDept. of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway; National Institute of Occupational Health, Oslo, Norway; Department of Biosciences, University of Oslo, Oslo, Norway.
Akershus University Hospital · NOOslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Earlier studies have shown that genetic variability in the SLC6A4 gene encoding the serotonin transporter (5-HTT) may be important for the re-uptake of serotonin (5-HT) in the central nervous system. In the present study we investigated how the 5-HTT genotype i.e. the short (S) versus long (L) 5-HTTLPR allele and the SNP rs25531 A > G affect the physical and psychosocial functioning in patients with chronic fatigue syndrome (CFS). All 120 patients were recruited from The Department of Paediatrics at Oslo University Hospital, Norway, a national referral center for young CFS patients (12-18 years). Main outcomes were number of steps per day obtained by an accelerometer and disability scored by the Functional Disability Inventory (FDI). Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype. Patients with the 5-HTT SS or SLG genotype also had a significantly higher FDI score than patients with the 5-HTT LALG, SLA or LALA genotype. Thus, CFS patients with the 5-HTT SS or SLG genotype had worse 30 weeks outcome than CFS patients with the 5-HTT LALG, SLA or LALA genotype. The present study suggests that the 5-HTT genotype may be a factor that contributes to maintenance of CFS.

Indexed as

GenotypePolymorphism, Single NucleotideAccelerometryAdolescentChildDouble-Blind MethodFatigue Syndrome, ChronicFemaleHumansMaleSerotoninSerotonin Plasma Membrane Transport ProteinsSerotoninSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID26473596
PMCPMC4608737
OpenAlexW1852066922

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.