Evidence map›Paper›PMID 26473365›Full record

ArticlePloS one2015

IL-10 Gene Polymorphisms Are Associated with Post-Bronchiolitis Lung Function Abnormalities at Six Years of Age.

Eero Lauhkonen, Petri Koponen, Johanna Teräsjärvi, Kirsi Gröndahl-Yli-Hannuksela, Juho Vuononvirta, Kirsi Nuolivirta, Jyri O Toikka, Merja Helminen, Qiushui He, Matti Korppi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Eero LauhkonenTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Petri KoponenTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Johanna TeräsjärviDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
Kirsi Gröndahl-Yli-HannukselaDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
Juho VuononvirtaDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
Kirsi NuolivirtaSeinäjoki Central Hospital, Seinäjoki, Finland.
Jyri O ToikkaDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Turku University Hospital, Turku, Finland.
Merja HelminenTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Qiushui HeDepartment of Medical Microbiology and Immunology, Turku University, Turku, Finland; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
Matti KorppiTampere Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
Tampere University Hospital · FIFinnish Institute for Health and Welfare · FIUniversity of Turku · FISeinäjoki University of Applied Sciences · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimInterleukin-10 (IL-10) has been associated with wheezing and asthma in children and the genetic variation of the IL-10 cytokine production may be linked to post-bronchiolitis lung function. We used impulse oscillometry (IOS) to evaluate the associations of IL10 polymorphisms with lung function at a median age of 6.3 years in children hospitalised for bronchiolitis before six months of age.

methodsWe performed baseline and post-exercise IOS on 103 former bronchiolitis patients. Data on single nucleotide polymorphisms (SNP) of IL10 rs1800896 (-1082G/A), rs1800871 (-819C/T), rs1800872 (-592C/A) were available for 99 children and of IL10 rs1800890 (-3575T/A) for 98 children.

resultsIL10 rs1800896, rs1800871 and rs1800872 combined genotype AA+CT+CA and carriage of haplotype ATA, respectively, were associated with higher resistance and lower reactance in baseline IOS in adjusted analyses. At IL10 rs1800890, the A/A-genotype and carriers of A-allele were associated with lower reactance in baseline IOS. There were no significant associations between the studied SNPs and airway hyper-reactivity to exercise.

conclusionLow-IL-10-producing polymorphisms in the IL-10 encoding gene were associated with obstructive lung function parameters, suggesting an important role for IL-10 in development of lung function deficit in early bronchiolitis patients.

Indexed as

Polymorphism, Single NucleotideBronchiolitisChildChild, PreschoolFemaleHumansInfantInterleukin-10LungMaleProspective StudiesRespiratory Function TestsIL10 protein, humanInterleukin-10

Identifiers

PMID26473365
PMCPMC4608806
OpenAlexW2336832606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.