Evidence map›Paper›PMID 26473342›Full record

ArticleComparative medicine2015

Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.

Bill Vestergaard, Łukasz Krych, Leif R Lund, Bettina P Jørgensen, Lars Hansen, Henrik E Jensen, Dennis S Nielsen, Axel K Hansen

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bill VestergaardDepartment of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. billvestergaard@hotmail.com.
Łukasz KrychDepartment of Departments of Food Science, University of Copenhagen, Frederiksberg, Denmark.
Leif R LundDepartment of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Bettina P JørgensenDepartment of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Lars HansenDepartment of Biology, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark.
Henrik E JensenDepartment of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Dennis S NielsenDepartment of Departments of Food Science, University of Copenhagen, Frederiksberg, Denmark.
Axel K HansenDepartment of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasminogen-deficient (FVB/NPan-plg(tm1Jld), plg(tm1Jld)) mice, which are widely used as a wound-healing model, are prone to spontaneous rectal prolapses. The aims of this study were 1) to evaluate the fecal microbiome of plg(tm1Jld) mice for features that might contribute to the development of rectal prolapses and colonic inflammation and 2) to assess the relevance of the inflammatory phenotype to the variability in wound healing in this model. The (plgtm1Jld) mice exhibited delayed wound healing, and they could be divided into 3 distinct groups that differed according to the time until wound closure. Colonic lesions in plg(tm1Jld) mice, which were characterized by necrotizing ulcerations and cystically dilated glands, were restricted to the intermediate and distal parts of the colon. The cytokine profile was indicative of chronic tissue damage, but the genetic modification did not change the composition of the gut microbiota, and none of the clinical or biochemical parameters correlated with the gut microbiota composition.

Indexed as

Gastrointestinal MicrobiomeAnimalsColitisColonCytokinesFecesGenetic Predisposition to DiseaseInflammation MediatorsMaleMice, 129 StrainMice, KnockoutNecrosisPhenotypePlasminogenRectal ProlapseTime FactorsCytokinesInflammation MediatorsPlasminogen

Identifiers

PMID26473342
PMCPMC4617329
OpenAlexW2443060240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.