ArticleJournal of cancer prevention2015
Association Between Grading of Oral Submucous Fibrosis With Frequency and Consumption of Areca Nut and Its Derivatives in a Wide Age Group: A Multi-centric Cross Sectional Study From Karachi, Pakistan.
Article in Journal of cancer prevention, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Cardiovascular profile and oral submucous fibrosis among long-term tobacco chewers.Bioinformation · 2025Article
- TUSC3, p53 and p21 genetic association with development of oral submucous fibrosis and oral squamous cell carcinoma among addictive tobacco chewers of Pakistan.BMC oral health · 2024Article
- Prevalence and risk factors of oral potentially malignant disorders in Indonesia: a cross-sectional study undertaken in 5 provinces.Scientific reports · 2024Article
- Sociodemographic and Clinical Profile of Oral Submucous Fibrosis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Review
- Arecoline aggravates acute ulcerative colitis in mice by affecting intestinal microbiota and serum metabolites.Frontiers in immunology · 2023Article
- Metabolomic Profile of Indonesian Betel Quids.Biomolecules · 2022Article
- Regulation of Jun and Fos AP-1 transcription factors by JNK MAPKs signaling cascade in areca nut extract treated KB cells.Biochemistry and biophysics reports · 2021Article
- Oral Submucous Fibrosis: Correlation of Clinical Grading to Various Habit Factors.Journal of International Society of Preventive & Community DentistryArticle
- Relationship of Clinical Features with Candidal Carriage in Oral Submucous Fibrosis Patients: A Case-control Study.Contemporary clinical dentistryArticle
- Correlation of blanching, fibrosis, and uvular changes with the extent of mouth opening in oral submucous fibrosis - A 9-year retrospective analysis.Journal of oral and maxillofacial pathology : JOMFPArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral submucous fibrosis (OSMF) is a chronic, premalignant condition of the oral mucosa and one of the commonest potentially malignant disorders amongst the Asian population. The objective of this study was to investigate the association of etiologic factors with: age, frequency, duration of consumption of areca nut and its derivatives, and the severity of clinical manifestations.
methodsA cross-sectional, multi centric study was conducted over 8 years on clinically diagnosed OSMF cases (n = 765) from both public and private tertiary care centers. Sample size was determined by World Health Organization sample size calculator. Consumption of areca nut in different forms, frequency of daily usage, years of chewing, degree of mouth opening and duration of the condition were recorded. Level of significance was kept at P ≤ 0.05.
resultsA total of 765 patients of OSMF were examined, of whom 396 (51.8%) were male and 369 (48.2%) female with a mean age of 29.17 years. Mild OSMF was seen in 61 cases (8.0%), moderate OSMF in 353 (46.1%) and severe OSMF in 417 (54.5%) subjects. Areca nut and other derivatives were most frequently consumed and showed significant risk in the severity of OSMF (P ≤ 0.0001). Age of the sample and duration of chewing years were also significant (P = 0.012).
conclusionsThe relative risk of OSMF increased with duration and frequency of areca nut consumption especially from an early age of onset.
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