ArticlePediatric gastroenterology, hepatology & nutrition2015
Diagnostic Value of Ceruloplasmin in the Diagnosis of Pediatric Wilson's Disease.
Article in Pediatric gastroenterology, hepatology & nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Reconsidering the Tolerable Upper Levels of Zinc Intake among Infants and Young Children: A Systematic Review of the Available Evidence.Nutrients · 2022Pooled it
- [Establishment of a Noninvasive Diagnostic Model for Wilson Disease Using Metallomics and Machine Learning].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- A cross-sectional assessment of the diagnostic value of serum ceruloplasmin for Wilson's disease in children.Medicine · 2026Article
- Treating the Neurologic Manifestations of Wilson's Disease With Liver Transplantation.The Neurohospitalist · 2024Article
- Pediatric reference interval verification for 16 biochemical markers on the Alinity ci system in the CALIPER cohort of healthy children and adolescents.Clinical chemistry and laboratory medicine · 2023Article
- Monitoring of Copper in Wilson Disease.Diagnostics (Basel, Switzerland) · 2023Review
- Assessment of the diagnostic value of serum ceruloplasmin for Wilson's disease in children.BMC gastroenterology · 2022Article
- Early Diagnosis of Wilson's Disease in Children in Southern China by Using Common Parameters.Frontiers in genetics · 2022Article
- Wilson Disease in Children; Chelation Therapy or Liver Transplantation? A 10-Year Experience from Pakistan.Annals of transplantation · 2021Article
- Wilson disease: revision of diagnostic criteria in a clinical series with great genetic homogeneity.Journal of gastroenterology · 2021Article
- Multiplex Ligation-dependent Probe Amplification Analysis Subsequent to Direct DNA Full Sequencing for IdentifyingJournal of Korean medical science · 2018Article
- Functional Characterization of NovelFrontiers in pediatrics · 2018Article
- The optimal threshold of serum ceruloplasmin in the diagnosis of Wilson's disease: A large hospital-based study.PloS one · 2018Article
- ATP7B Mutation Detection and Pathogenicity Analysis: One Atypical Case of Wilson's Disease with Adrenocortical Insufficiency.Journal of molecular neuroscience : MN · 2018Article
- Four-year follow-up of a Wilson disease pedigree complicated with epilepsy and hypopituitarism: Case report with a literature review.Medicine · 2016Review
- Change in pulmonary function tests and their relation to the serum levels of ceruloplasmin, copper and superoxide dismutase in patients suffering from Type-1 and Type-2 diabetes.Pakistan journal of medical sciencesArticle
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMeasurement of serum ceruloplasmin level is the first step in screening for Wilson's disease (WD). Despite the rarity of WD in the general population, ceruloplasmin levels are routinely measured through hepatitis screening in both adults and children. Herein, we evaluated the diagnostic value of ceruloplasmin for the diagnosis of WD among children with hepatitis.
methodsWe retrospectively reviewed data on serum ceruloplasmin levels measured as a serologic marker for patients with hepatitis at Asan Medical Center (Seoul, Korea) between from January 2004 to November 2013. The diagnosis of WD was confirmed by the identification of pathogenic variants in the ATP7B gene. To determine the diagnostic accuracy of ceruloplasmin, receiver operation characteristic (ROC) curves were constructed and the area under curve (AUC) were calculated.
resultsMeasurements of serum ceruloplasmin were performed in 2,834 children who had hepatitis. Among these, 181 (6.4%) children were diagnosed with WD. The sensitivity, specificity, and accuracy of a ceruloplasmin level of <20 mg/dL in the discrimination of WD were 93.4%, 84.2%, and 84.8%, respectively. In this study, 418 (14.7%) false-positive cases and 12 (0.4%) false-negative cases were noted. Using a ROC curve, a ceruloplasmin level of ≤16.6 mg/dL showed the highest AUC value (0.956) with a sensitivity of 91.2%, a specificity of 94.9%, and an accuracy of 94.7%.
conclusionThe measurement of serum ceruloplasmin was frequently used for the screening of WD in children, despite a low positive rate. The diagnostic value of ceruloplasmin may be strengthened by adopting a new lower cut-off level.
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