ArticleIranian Red Crescent medical journal2015
Wound Healing Activity of a Traditionally Used Poly Herbal Product in a Burn Wound Model in Rats.
Article in Iranian Red Crescent medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- The Influence of Phyto-Active Incorporated Topical Formulations on Cell Migration in Scratch Assays andCurrent drug delivery · 2026Article
- Phytomedicines and conventional drugs in scabies management.GMS hygiene and infection control · 2026Review
- Beneficial Effects of Quadri Herb (QH) Ointment on Second-Degree Burn Scald: An In Vivo Study.BioMed research international · 2026Article
- Antioxidant Potential of Medicinal Plants in the Treatment of Scabies Infestation.Molecules (Basel, Switzerland) · 2024Review
- Medicinal plants used for cutaneous wound healing in Uganda; ethnomedicinal reports and pharmacological evidences.Heliyon · 2024Review
- Evaluation of Wound Healing Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root ofJournal of experimental pharmacology · 2024Article
- Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review.Frontiers in pharmacology · 2024Review
- Antimicrobial, Anti-inflammatory, and Wound Healing Properties ofBioMed research international · 2024Article
- Remnants from the Past: From an 18th Century Manuscript to 21st Century Ethnobotany in Valle Imagna (Bergamo, Italy).Plants (Basel, Switzerland) · 2023Article
- The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn-A Review.Pharmaceutics · 2023Review
- Evaluation of the Antioxidant and Wound Healing Properties of 80% Methanol Extract and Solvent Fractions of the Leaves ofClinical, cosmetic and investigational dermatology · 2023Article
- Impact of Rose Water Mouthwash on Prevention of Ventilator-Associated Pneumonia in Intensive Care Unit: A Randomized Controlled Trial.Tanaffos · 2023Article
- Evaluation of Wound Healing Activity of 80% Methanol Stem-Bark Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Evaluation of Wound Healing and Anti-Inflammatory Activities of 80% Methanol Crude Extract and Solvent Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate andDrug delivery · 2022Article
- Cinnamaldehyde-Based Self-Nanoemulsion (CA-SNEDDS) Accelerates Wound Healing and Exerts Antimicrobial, Antioxidant, and Anti-Inflammatory Effects in Rats' Skin Burn Model.Molecules (Basel, Switzerland) · 2022Article
- The effect of mesenchymal stem cell-conditioned medium gel on burn wound healing in rat.Veterinary world · 2022Article
- Bio-Evaluation of the Wound Healing Activity ofAntioxidants (Basel, Switzerland) · 2022Article
- Evaluation of Wound Healing Activity of 80% Methanol Root Crude Extract and Solvent Fractions ofJournal of experimental pharmacology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurns are known as one of the most common and destructive forms of injury with a vast spectrum of consequences. Despite the discovery of various antibacterial and antiseptic agents, burn wound healing still has remained a challenge to modern medicine. Plants, with a valuable traditional support, have been considered as potential agents for prevention and treatment of disorders in recent years. However, modern scientific methods should be applied to validate the claims about the therapeutic effects of the herbal products.
objectivesThis study was conducted to evaluate the wound-healing activity of a poly herbal cream (PHC), retrieved from Iranian Traditional Medicine (ITM), in a rat burn wound model in Iran. MATERIALS AND
methodsIn this experimental study, PHC containing aqueous extracts of Malva sylvestris and Solanum nigrum leaves and oily extract of Rosa damascena petals was used. Second-degree burn wounds were induced in four groups of five rats each. Group 1 received no treatment while groups 2, 3 and 4 were given cream base, silver sulfadiazine (SS) 1% and PHC, respectively to compare the efficacy of PHC with the negative and positive control groups. The percentage of wound healing on days 2, 6, 10 and 14 and histopathological parameters of healed wounds on the 14th day were assessed. Antioxidant and antimicrobial activities of PHC were evaluated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and micro-dilution methods, respectively.
resultsThere was a significant improvement in healing percentage of PHC-treated rats in comparison to the other groups at the end of the treatment period (87.0% ± 2.1% for PHC in comparison to 32.2% ± 1.6%, 57.0% ± 5.3% and 70.8% ± 3.5% for the control, cream base and SS groups, respectively). Moreover, the healed wounds in PHC-treated animals contained less inflammatory cells and had desirable re-epithelialization with remarkable neovascularization. In addition to the antioxidant activity, PHC exhibited antibacterial effect against Staphylococcus aureus.
conclusionsPoly herbal cream experimentally and histopathologically revealed a burn wound healing activity probably due to the antioxidant, anti-inflammatory and antimicrobial activities of its phytochemical contents. Therefore, this study confirms the use of M. sylvestris, S. nigrum and R. damascena in burn prescriptions in ITM.
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