ReviewJournal of breast cancer2015
Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem.
Review in Journal of breast cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The potential benefits of radiotherapy in elderly patients with early-stage triple-negative breast cancer.Frontiers in medicine · 2024Article
- Comparison of breast-conserving surgery without radiotherapy and mastectomy in the treatment of elderly patients with early breast cancer: A PSM and SEER database study.Cancer medicine · 2023Article
- Characteristics and chronologically changing patterns of late-onset breast cancer in Korean women of age ≥ 70 years: A hospital based-registry study.BMC cancer · 2022Article
- Development of a novel five-lncRNA prognostic signature for predicting overall survival in elderly patients with breast cancer.Journal of clinical laboratory analysis · 2022Article
- Defining Undertreatment and Overtreatment in Older Adults With Cancer: A Scoping Literature Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020Article
- Association of Axillary Lymph Node Evaluation With Survival in Women Aged 70 Years or Older With Breast Cancer.Frontiers in oncology · 2020Article
- Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid.Drug delivery · 2019Article
- Epidermal growth factor receptor-mediated regulation of matrix metalloproteinase-2 and matrix metalloproteinase-9 in MCF-7 breast cancer cells.Molecular and cellular biochemistry · 2019Article
- The Relationship of Age and Postoperative Pain in Women after Surgery for Breast Cancer.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2018Article
- Current Strategies of Endocrine Therapy in Elderly Patients with Breast Cancer.BioMed research international · 2018Review
- Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise.Frontiers in pharmacology · 2018Review
- Meningioma and breast cancer: survival of patients with synchronous and metachronous meningioma and breast cancer.Journal of neuro-oncology · 2018Article
- Impact of social and clinical factors on diagnostic delay of breast cancer: A Cross-sectional Study.Medicine · 2016Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer generally develops in older women and its incidence is continuing to increase with increasing age of the population. The pathology and biology of breast cancer seem to be different in the elderly, often resulting in the undertreatment of elderly patients and thus in higher rates of recurrence and mortal-ity. The aim of this review is to describe the differences in the biology and treatment of early breast cancer in the elderly as well as the use of geriatric assessment methods that aid decision-making. Provided there are no contraindications, the cornerstone of treatment should be surgery, as the safety and efficacy of surgical resection in elderly women have been well documented. Because most breast cancers in the elderly are hormone responsive, hormonal therapy remains the mainstay of systemic treatment in the adjuvant setting. The role of chemotherapy is limited to patients who test negative for hormone receptors and demonstrate an aggressive tumor profile. Although the prognosis of breast cancer patients has generally improved during the last few decades, there is still a demand for evidence-based optimization of therapeutic interventions in older patients.
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