ArticleLaboratory animal research2015
Extraction conditions of white rose petals for the inhibition of enzymes related to skin aging.
Article in Laboratory animal research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Green Extraction Strategies for Rose Bioactives: Impacts on Chemical Composition and Anti-Aging Efficacy.ACS omega · 2026Article
- Pyrogallol Contributes to the Anti-Allergic and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses.Current issues in molecular biology · 2026Article
- A Comprehensive Review of Edible Flowers with a Focus on Microbiological, Nutritional, and Potential Health Aspects.Foods (Basel, Switzerland) · 2025Review
- Research on the mechanisms of plant bioactive metabolites in anti-skin aging and future development prospects.Frontiers in pharmacology · 2025Review
- Antioxidative and Anti-Inflammatory Activities of Rosebud Extracts of Newly Crossbred Roses.Nutrients · 2023Article
- Antioxidative Role ofAntioxidants (Basel, Switzerland) · 2022Article
- Metabolite and Elastase Activity Changes in Beach Rose (Plants (Basel, Switzerland) · 2021Article
- Article
- The Ethanol Fraction of White Rose Petal Extract Abrogates Excitotoxicity-Induced Neuronal DamageNutrients · 2018Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to assess inhibitory potentials of white rose petal extracts (WRPE) on the activities of enzymes related to dermal aging according to the extraction conditions, three extraction methods were adopted. WRPE was prepared by extracting dried white rose (Rosa hybrida) petals with 50% ethanol (WRPE-EtOH), Pectinex® SMASH XXL enzyme (WRPE-enzyme) or high temperature-high pressure (WRPE-HTHP). In the inhibition of matrix metalloproteinase-1, although the enzyme activity was fully inhibited by all 3 extracts at 100 µg/mL in 60 min, partial inhibition (50-70%) was achieved only by WRPE-EtOH and WRPE-enzyme at 50 µg/mL. High concentrations (≥250 µg/mL) of all 3 extracts markedly inhibited the elastase activity. However, at low concentrations (15.6-125 µg/mL), only WRPE-EtOH inhibited the enzyme activity. Notably, WRPE-EtOH was superior to WRPE-enzyme and WRPE-HTHP in the inhibition of tyrosinase. WRPE-EtOH significantly inhibited the enzyme activity from 31.2 µM, reaching 80% inhibition at 125 µM. In addition to its strong antioxidative activity, the ethanol extract of white rose petals was confirmed to be effective in inhibiting skin aging-related enzymes. Therefore, it is suggested that WRPE-EtOH could be a good candidate for the improvement of skin aging such as wrinkle formation and pigmentation.
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