ArticleCirculation research2016
Tissue-Specific Cell Cycle Indicator Reveals Unexpected Findings for Cardiac Myocyte Proliferation.
Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Cell cycle visualization tools to study cardiomyocyte proliferation in real-time.Open biology · 2024Review
- Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny.American journal of physiology. Heart and circulatory physiology · 2023Article
- Cardiomyocyte-fibroblast crosstalk in the postnatal heart.Frontiers in cell and developmental biology · 2023Review
- Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation.Fundamental research · 2022Article
- Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle.Nature communications · 2021Article
- Mechanism-Based Cardiac Regeneration Strategies in Mammals.Frontiers in cell and developmental biology · 2021Review
- Fluorescent indicators for continuous and lineage-specific reporting of cell-cycle phases in human pluripotent stem cells.Biotechnology and bioengineering · 2020Article
- Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations.Trends in endocrinology and metabolism: TEM · 2019Review
- Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice.Frontiers in cell and developmental biology · 2019Article
- Single-cell imaging and transcriptomic analyses of endogenous cardiomyocyte dedifferentiation and cycling.Cell discovery · 2019Article
- Neonatal Heart Regeneration: Comprehensive Literature Review.Circulation · 2018Article
- New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications.Circulation research · 2018Review
- Cardiomyocyte Proliferation for Therapeutic Regeneration.Current cardiology reports · 2018Review
- Analysis of cardiomyocyte clonal expansion during mouse heart development and injury.Nature communications · 2018Article
- Resident fibroblast expansion during cardiac growth and remodeling.Journal of molecular and cellular cardiology · 2018Article
- Novel large-particle FACS purification of adult ventricular myocytes reveals accumulation of myosin and actin disproportionate to cell size and proteome in normal post-weaning development.Journal of molecular and cellular cardiology · 2017Article
- Wnt11 regulates cardiac chamber development and disease during perinatal maturation.JCI insight · 2017Article
- EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.eLife · 2017Article
- Redirecting cardiac growth mechanisms for therapeutic regeneration.The Journal of clinical investigation · 2017Review
- Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.The Journal of clinical investigation · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
rationaleDiscerning cardiac myocyte cell cycle behavior is challenging owing to commingled cell types with higher proliferative activity.
objectiveTo investigate cardiac myocyte cell cycle activity in development and the early postnatal period. METHODS AND
resultsTo facilitate studies of cell type-specific proliferation, we have generated tissue-specific cell cycle indicator BAC transgenic mouse lines. Experiments using embryonic fibroblasts from CyclinA2-LacZ-floxed-EGFP, or CyclinA2-EGFP mice, demonstrated that CyclinA2-βgal and CyclinA2-EGFP were expressed from mid-G1 to mid-M phase. Using Troponin T-Cre;CyclinA2-LacZ-EGFP mice, we examined cardiac myocyte cell cycle activity during embryogenesis and in the early postnatal period. Our data demonstrated that right ventricular cardiac myocytes exhibited reduced cell cycle activity relative to left ventricular cardiac myocytes in the immediate perinatal period. Additionally, in contrast to a recent report, we could find no evidence to support a burst of cardiac myocyte cell cycle activity at postnatal day 15.
conclusionsOur data highlight advantages of a cardiac myocyte-specific cell cycle reporter for studies of cardiac myocyte cell cycle regulation.
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