SynthesisSchizophrenia bulletin2016
Altered Hub Functioning and Compensatory Activations in the Connectome: A Meta-Analysis of Functional Neuroimaging Studies in Schizophrenia.
Synthesis in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Beyond fear circuits: multiscale neurobiological architecture of panic disorder.Molecular psychiatry · 2026Pooled it
- Prevalence of Neuroradiological Abnormalities in First-Episode Psychosis: A Systematic Review and Meta-analysis.JAMA psychiatry · 2023Pooled it
- Dysfunction of Large-Scale Brain Networks in Schizophrenia: A Meta-analysis of Resting-State Functional Connectivity.Schizophrenia bulletin · 2018Pooled it
- Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders.Human brain mapping · 2017Pooled it
- Meta-connectomics: human brain network and connectivity meta-analyses.Psychological medicine · 2016Pooled it
- Disrupted Topological Patterns of Large-Scale Network in Conduct Disorder.Scientific reports · 2016Trial
- Hybrid Evidence-Informed Synthesis of Resting-State Functional Connectivity Alterations in Mild Traumatic Brain Injury.Brain sciences · 2026Review
- Altered functional connectivity of the hippocampus in cortico-subcortical networks in early-stage and emerging psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- GABAMolecular psychiatry · 2026Article
- The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex.Psychiatry research. Neuroimaging · 2024Article
- Alterations in the hub structure of whole-brain functional networks in patients with drug-naïve schizophrenia: Insights from electroencephalography-based research.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.Schizophrenia research · 2023Article
- Exploring the role of hub and network dysfunction in brain connectomes of schizophrenia using functional magnetic resonance imaging.Frontiers in psychiatry · 2023Article
- Decreased cortical gyrification and surface area in the left medial parietal cortex in patients with treatment-resistant and ultratreatment-resistant schizophrenia.Psychiatry and clinical neurosciences · 2023Article
- Inefficient white matter activity in Schizophrenia evoked during intra and inter-hemispheric communication.Translational psychiatry · 2022Article
- Aberrant Subnetwork and Hub Dysconnectivity in Adult Bipolar Disorder: A Multicenter Graph Theory Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- A systematic review of the neural correlates of multisensory integration in schizophrenia.Schizophrenia research. Cognition · 2022Article
- Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome.Scientific reports · 2021Article
- Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis.Scientific reports · 2021Article
- Interhemispheric co-alteration of brain homotopic regions.Brain structure & function · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundFunctional neuroimaging studies of schizophrenia have identified abnormal activations in many brain regions. In an effort to interpret these findings from a network perspective, we carried out a meta-analysis of this literature, mapping anatomical locations of under- and over-activation to the topology of a normative human functional connectome.
methodsWe included 314 task-based functional neuroimaging studies including more than 5000 patients with schizophrenia and over 5000 controls. Coordinates of significant under- or over-activations in patients relative to controls were mapped to nodes of a normative connectome defined by a prior meta-analysis of 1641 functional neuroimaging studies of task-related activation in healthy volunteers.
resultsUnder-activations and over-activations were reported in a wide diversity of brain regions. Both under- and over-activations were significantly more likely to be located in hub nodes that constitute the "rich club" or core of the normative connectome. In a subset of 121 studies that reported both under- and over-activations in the same patients, we found that, in network terms, these abnormalities were located in close topological proximity to each other. Under-activation in a peripheral node was more frequently associated specifically with over-activation of core nodes than with over-activation of another peripheral node.
conclusionsAlthough schizophrenia is associated with altered brain functional activation in a wide variety of regions, abnormal responses are concentrated in hubs of the normative connectome. Task-specific under-activation in schizophrenia is accompanied by over-activation of topologically central, less functionally specialized network nodes, which may represent a compensatory response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.